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. 2021 May 24;12:3039. doi: 10.1038/s41467-021-23171-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–i Circos plots displaying breakpoints and CNVs along chromosomes. The breakpoints are displayed in blue, if within chromosomes, or red, if between chromosomes. Copy number gains along the outer track are shown in dark red, with losses indicated in blue and neutral copies in dark gray. The annotations at the periphery of the plots for the first time point of each patient indicate CNVs and SVs (breakpoints) affecting the exons of COSMIC cancer census genes. The plots for the subsequent time points are annotated to show only acquired CNVs and SVs, with truncal breakpoints shown in light gray.