Skip to main content
. 2021 May 24;12:3059. doi: 10.1038/s41467-021-23285-8

Fig. 6. AAV8-mediated reintroduction of PPDPF and PPDPF-mut in PPDPF-LKO mice.

Fig. 6

The liver TG test (a) and NEFA test (b) of WT + con, LKO + con, LKO + PPDPF, and LKO + PPDPF mut mice (n = 5 per group) at 8 months on chow diets. Mean ± SEM, n.s (not significant), ****p < 0.0001 by two-tailed unpaired Student’s t test. c Representative images of H&E and Oil Red O staining of liver sections from the mice injected with indicated adenovirus at 8 months. Scale bars, 100 um. d Expression of p-S6K, S6K, SREBP1 and FASN in the liver tissues of WT + con, LKO + con, LKO + PPDPF and LKO + PPDPF mut mice (n = 3 per group) fed HFD for 3 months. The liver TG test (e) and NEFA test (f) of WT + con, LKO + con, LKO + PPDPF, and LKO + PPDPF mut mice (n = 5 per group) fed HFD for 3 months. Mean ± SEM, n.s (not significant), ****p < 0.0001 by two-tailed unpaired Student’s t-test. g Representative images of H&E and Oil Red O staining of liver sections from the mice injected with indicated adenovirus fed HFD for 3 months. Scale bars, 100 um. h Expression of p-S6K, S6K, SREBP1, and FASN in each group in HFD mouse model. All experiments were repeated three times independently.