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. 2021 May 24;12:3054. doi: 10.1038/s41467-021-22930-6

Fig. 5. Temporal gene expression analysis after rDEN2Δ30 infection by logical conjunction analysis (LCA).

Fig. 5

a Schematic overview of LCA. Genes have undergone regulation if for all 11 subjects the regulation occurred in the same direction (e.g., up) and had a P value < 0.05 and FDR < 0.1. No minimum fold-change criteria was applied for Threshold. b F × E plots (log2 fold-change × expression, in counts per million reads (CPM)) of pairwise timepoint comparisons for genes meeting threshold of P < 0.05 and FDR < 0.1 and ≥4 counts per million reads (CPM). Examples of genes regulated |≥1.5-fold| are labeled (c) Venn diagram of gene expression changes by timepoint. Triangles indicate directionality of gene regulation in timepoint comparison. d DAVID Pathway analysis of Viremia-Tracking genes (e) DAVID pathway analysis of post-viremia genes. Directionality is not shown because the pathway definition incorporates three timepoints. Source data are provided as a Source Data file.