Table 1.

Summary for the results of univariate and multivariable analysis.

Factors		OS (overall survival)					EFS (event-free survival)
	Number of Patients	Univariate		Multivariate			Univariate		Multivariate
		HR	p-value	HR	95% CI	p-value	HR	p-value	HR	95% CI	p-value
Age	345	1.0309	0.1081	1.0385	0.9960–1.0828	0.0764	1.0245	0.1421	1.0380	1.0008–1.0767	0.0453
Beta-2 microglobulin	345	1.0819	0.0000	1.0734	1.0212–1.1282	0.0053	1.0770	0.0000	1.0530	1.0055–1.1027	0.0283
C-reactive protein	345	1.0041	0.4113	0.9882	0.9710–1.0057	0.1841	1.0096	0.0045	1.0013	0.9917–1.0109	0.7958
Creatinine	345	1.2250	0.0035	1.0848	0.8580–1.3717	0.4964	1.2504	0.0001	1.1106	0.9120–1.3523	0.2967
Lactate dehydrogenase	345	1.0083	0.0000	1.0103	1.0057–1.0150	0.0000	1.0081	0.0000	1.0077	1.0037–1.0118	0.0002
Albumin	345	0.5633	0.0005	0.6611	0.4469–0.9780	0.0383	0.5826	0.0003	0.7157	0.5016–1.0211	0.0651
Haemoglobin	345	0.8082	0.0216	0.9508	0.7418–1.2187	0.6906	0.7604	0.0013	0.8868	0.7130–1.1030	0.2807
Aspirate plasma cells	345	1.0069	0.2831	1.0050	0.9896–1.0206	0.5272	1.0079	0.1653	1.0081	0.9947–1.0217	0.2361
Bone marrow biopsy plasma cells	345	1.0126	0.0366	1.0138	0.9979–1.0300	0.0894	1.0131	0.0141	1.0083	0.9947–1.0221	0.2342
Number of foal lesions under MRI	345	1.0191	0.0247	1.0238	1.0042–1.0438	0.0173	1.0146	0.0669	1.0171	0.9995–1.0351	0.0570
ITGA6	345	0.7652	0.0057	0.7270	0.5829–0.9068	0.0047	0.8005	0.0136	0.7946	0.6507–0.9703	0.0241
ISS		1.6141	0.0099	0.5505	0.2998–1.0109	0.0542	1.6166	0.0092	0.6503	0.3905–1.0828	0.0981
ISS II	272
ISS III	73

MRI magnetic resonance imaging, EFS the length of time after primary treatment for a cancer ends that the patient remains free of certain complications or events that the treatment was intended to prevent or delay.