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. 2021 May 24;12:3038. doi: 10.1038/s41467-021-23400-9

Fig. 1. Overall structure of infectious MAYV determined by cryo-EM.

Fig. 1

A MAYV particle showing the external surface with assigned symmetry axes. The white dashed triangle indicates the icosahedral asymmetric unit. Polygons indicate the fivefold axis (pentagon), three and quasi threefold axes (triangles), and twofold axis (circle). MAYV density map is in surface representation and coloured by local resolution estimated using ½-bit threshold criterion in Imagic-4D software system. Scale bar indicates the calculated local resolution. The local resolution values range from 3.7 to 7.8, with median of 4.2. B MAYV 3D atomic model fitted into the density map. For clarity, only backbone atoms are presented. The model shows coloured MAYV proteins. 5-3-2 symmetry axes and the asymmetric unit are the same as in (A). C, D Central cross-section of the MAYV density map or atomic model, respectively. E Two rotated views of MAYV asymmetric unit formed by four E1–E2 heterodimers following icosahedral T = 4 triangulation. Three and quasi threefold axes are indicated.