TABLE 1.

Roles of METTL3 in HCC.

Target RNAs	Signaling pathways	Biological processes	Cellular function	References
SOCS2	JAK/STAT signaling		Cell proliferation, migration	Chen et al., 2018
RDM1	Calcium signaling, Ras/Raf/ERK signaling, p53 signaling		Cell survival, proliferation, stability	Chen S. L. et al., 2020
SNAI1		EMT	Cell invasion and metastasis	Xu et al., 2020
	mTORC1 signaling	Metabolic reprogramming	Cell proliferation, migration, invasion	Yang N. et al., 2020
HIF-1α		Metabolic reprogramming	Cell proliferation, migration, invasion	Lin Y. et al., 2020
LINC00958		lipogenesis	Cell growth, invasion, migration	Zuo et al., 2020
FOXO3		autophagy	Cell survival, sorafenib resistance	Lin Z. et al., 2020

Some potential targets of METTL3 have already been researched and discovered to be associated with the carcinogenesis, progression, and sorafenib-resistance process of HCC.