TABLE 1.
ID variable | Variable | Units | Low | High | Minimum | Maximum | N | Clinical criteria references |
Clinical criteria | Project 42 controls | |||||||
D0 | Sex | |||||||
D1 | Age | Years old | 18 | 27 | 47 | |||
P0 | Systolic blood pressure (SBP) | mmHg | 90 | 120 | 90 | 120 | 75 | Whelton et al., 2018 |
P1 | Diastolic blood pressure (DBP) | mmHg | 60 | 80 | 60 | 80 | 76 | Whelton et al., 2018 |
DP0 | Pulse pressure (PP) | mmHg | 20 | 60 | 30 | 60 | 75 | Whelton et al., 2018 |
DP1 | Mean arterial pressure (MAP) | mmHg | 70 | 93 | 70 | 93 | 75 | Whelton et al., 2018 |
T0 | Axillary temperature | °C | 35.5 | 37 | 35.2 | 37 | 26 | Sund-Levander et al., 2002 |
T1 | Tympanic temperature | °C | 35.4 | 37.8 | 35.1 | 37.6 | 19 | Sund-Levander et al., 2002 |
T2 | Wrist temperature | °C | 37.5 | 34.9 | 36.7 | 19 | Holt et al., 2020 | |
B0 | Weight | kg | 46.1 | 86.2 | 76 | |||
B1 | Height | m | 1.6 | 1.53 | 1.85 | 76 | Grimberg et al., 2016 | |
DB1 | Body mass index (BMI) | kg/m2 | 18 | 27 | 18 | 27.3 | 76 | Wall-Medrano et al., 2016 |
B2 | Waist | cm | 90 | 63 | 93.5 | 75 | Almeda-Valdes et al., 2016 | |
B3 | Hip | cm | 77.5 | 111 | 75 | Almeda-Valdes et al., 2016 | ||
B4 | Arm circumference | cm | 24 | 22 | 35 | 72 | Tang et al., 2020 | |
B6 | Triceps | cm | 2 | 30 | 76 | |||
B7 | Biceps | cm | 0 | 40 | 76 | |||
B8 | Suprailiac | cm | 0 | 36 | 75 | |||
B9 | Subscapular | cm | 0 | 54 | 76 | |||
DB2 | Waist to hip ratio | 0.95 | 0.72 | 0.92 | 75 | Lear et al., 2010 | ||
DB3 | Waist to height ratio | 0.54 | 0.377 | 0.548 | 75 | Almeda-Valdes et al., 2016 | ||
B10 | Body fat | % | 7.2 | 38 | 74 | |||
B11 | Body water | % | 48.5 | 71 | 58 | |||
DB4 | Body fat | kg | 3.5352 | 21.5352 | 74 | Freedman et al., 2012 | ||
DB5 | Total body water | kg | 26.78 | 51.01 | 58 | Chumlea et al., 2001 | ||
M1 | Triglycerides | mg/dL | 40 | 150 | 40 | 126 | 20 | Mach et al., 2020 |
M2 | Total cholesterol | mg/dL | 200 | 109 | 200 | 20 | Mach et al., 2020 | |
M3 | HDL cholesterol | mg/dL | 40 | 90 | 41.6 | 67.3 | 8 | Mach et al., 2020 |
M4 | LDL cholesterol | mg/dL | 116 | 58.2 | 109.7 | 8 | Mach et al., 2020 | |
M5 | Glucose | mg/dL | 70 | 100 | 70 | 94 | 20 | Alberti et al., 2009 |
M6 | Basal insulin | μUI/mL | 2.6 | 24.9 | 2.5 | 9.04 | 20 | |
M7 | Urea | mg/dL | 10 | 50 | 19.26 | 48 | 20 | Tyagi and Aeddula, 2020 |
M8 | Blood urea nitrogen (BUN) | mg/dL | 9 | 23 | 9 | 22.42 | 20 | Tyagi and Aeddula, 2020 |
M9 | Uric acid | mg/dL | 6.8 | 3.27 | 6.81 | 20 | Khanna et al., 2012 | |
M10 | Serum creatinine | mg/dL | 0.8 | 1.5 | 0.82 | 1.2 | 20 | Hosten, 1990 |
M12 | Glycosylated hemoglobin (HbA1c) | % | 5.7 | 4.7 | 5.8 | 20 | American Diabetes Association, 2020 | |
M13 | C-reactive protein | mg/L | 0 | 0.65 | 0.009 | 0.319 | 8 | Oda et al., 2006 |
M17 | Calcium | mmol/L | 8.8 | 10.7 | 9.2 | 10.3 | 12 | Shrimanker et al., 2019 |
M18 | Phosphorus | mmol/L | 2.3 | 6 | 2.6 | 4.4 | 12 | |
M19 | Total bilirubin | mg/dL | 0.2 | 1.3 | 0.51 | 0.95 | 12 | Zhang et al., 2017 |
M20 | Direct bilirubin | mg/dL | 0 | 0.3 | 0.22 | 0.33 | 12 | Zhang et al., 2017 |
M21 | Indirect bilirubin | mg/dL | 0.09 | 0.65 | 0.29 | 0.62 | 12 | Zhang et al., 2017 |
M22 | Aspartate aminotransferase | IU/L | 5 | 35 | 18 | 28 | 12 | Lala et al., 2020 |
DM0 | Homeostasis model assessment of insulin resistance (HOMA IR) | 1.7 | 0.488 | 1.708 | 20 | Esteghamati et al., 2009 | ||
DM1 | Estimated glomerular filtration rate (eGFR) | ml/min | 90 | 120 | 85 | 126 | 16 | Musso et al., 2016 |
DM2 | Estimated average glucose (eAG) | mg/dL | 88.19 | 119.76 | 20 | Guo et al., 2020 | ||
DM3 | eAG– fasting glucose | mg/dL | 5.06 | 31.76 | 20 | Guo et al., 2020 | ||
DM4 | BUN to creatinine ratio | 8.17 | 21.69 | 20 | Haines et al., 2019 | |||
H0 | Leukocytes | 109/L | 3.5 | 12 | 4.4 | 8.5 | 13 | Leung et al., 2020 |
H1 | Neutrophils | 109/L | 1.9 | 8 | 1.99 | 5.92 | 13 | Coates et al., 2020 |
DH1 | Total neutrophils percentage | % | 40 | 70 | 40 | 70 | 13 | Coates et al., 2020 |
H2 | Segmented neutrophils percentage | % | 39.7 | 69.6 | 11 | |||
H3 | Lymphocytes | 109/L | 1.5 | 3 | 1.44 | 3.25 | 12 | Rosenthal, 2020 |
DH2 | Lymphocytes percentage | % | 20 | 40 | 23.1 | 47.34 | 12 | Rosenthal, 2020 |
H4 | Monocytes | 103/L | 0.16 | 1 | 0.24 | 0.68 | 13 | Steensma and Bolton, 2020 |
DH3 | Monocytes percentage | % | 0 | 10 | 4 | 10.01 | 13 | Steensma and Bolton, 2020 |
H5 | Eosinophils | 103/L | 0 | 0.8 | 0.01 | 0.33 | 13 | Rosenthal, 2020 |
DH4 | Eosinophils percentage | % | 0 | 5 | 0.1 | 5.1 | 13 | Rosenthal, 2020 |
H6 | Basophils | 103/L | 0 | 0.2 | 0.01 | 0.199 | 13 | Rosenthal, 2020 |
DH5 | Basophils percentage | % | 0 | 1 | 0.1 | 1.2 | 12 | Rosenthal, 2020 |
H7 | Erythrocytes | 1012/L | 4.6 | 6.2 | 4.8 | 6.1 | 13 | Adeli et al., 2015 |
H8 | Hemoglobin | g/dL | 14.9 | 18.7 | 14.8 | 17.9 | 13 | Adeli et al., 2015 |
H9 | Hematocrit | % | 40 | 54 | 43.2 | 54.1 | 13 | Adeli et al., 2015 |
H10 | Mean corpuscular volume | fL | 76 | 100 | 79.1 | 96 | 13 | Leung et al., 2020 |
H11 | Mean concentration of hemoglobin | pg/RBC | 27.5 | 33.2 | 25.5 | 31.8 | 13 | Leung et al., 2020 |
H12 | Mean corpuscular hemoglobin concentration | g/dL | 32.5 | 35.2 | 31.5 | 33.9 | 11 | Leung et al., 2020 |
H13 | Red cell width distribution | % | 11.4 | 13.5 | 12.3 | 14.6 | 11 | Leung et al., 2020 |
H14 | Platelets | 103/μL | 147 | 384 | 159 | 340 | 13 | Leung et al., 2020 |
H15 | Mean platelet volume | fL | 6 | 13.2 | 6.1 | 10.3 | 11 | Leung et al., 2020 |