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. 2021 May 24;12:3046. doi: 10.1038/s41467-021-23379-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Unsupervised clustering by principal component analysis (PCA) on sample-wise PDO transcriptome. Organoids derived from the same subtypes were well clustered into the corresponding subtypes. b Top differentiated pathways between EC-type and SC-type PDOs according to GSEA enrichment analysis. c Upregulated signature genes in EC-type organoids (blue) and in SC-type organoids (red) overlapped by DESeq2 and Limma-voom. d Heatmap showing expression of differentiated signature genes between EC-type and SC-type organoids.