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. 2021 May 24;12:3044. doi: 10.1038/s41467-021-23237-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Differential ATAC-seq peaks in recurrent versus non-recurrent patients (Source data are provided as a Source Data file). b Upper panel depicts genome browser tracks showing ATAC-seq peaks at KRT19 and TUSC3 gene loci for duplicate samples from individual patients (PT); lower panel shows corresponding ENCODE methylation signals from Panc-1 and a normal pancreatic (BC) cell lines, (green denotes hypomethylation and red denotes hypermethylation) and DHS peak from Panc-1 and HPDE6-E6E7 cell lines. Highlighted yellow regions denote the promoter peaks of both the gene loci. All the track lines have the same Y axis limits and that the peak height is normalized by the total read depth of each sample. c Regression coefficients showing enrichment of transcription factor-binding sites in recurrent (red) and non-recurrent (blue) patients. d Representative images of TMA staining of HNF1b (upper panel) and ZKSCAN1 (lower panel) in recurrent and non-recurrent patients (TMA n = 43 with three replicated cores in each patient), Scale bars are 20 μM as displayed at the left bottom corners of all the micrographs. e Kaplan–Meier curve of the patients with and without nuclear localization of HNF1b (log-rank (Mantel–Cox) test P = 0.011, HR 2.64, 95% CI 1.213 to 5.775). (Source data are provided as a Source Data file).