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. 2021 May 24;11:10763. doi: 10.1038/s41598-021-89578-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Drug-target protein network analysis for anti-coronavirus drugs. (A) The network analysis of 48 coronavirus drugs collected in our study. The red box represents the drug; The blue circle represents the target protein. The OmicsViz interactive interface lets you zoom in and out. The network can also be extended by combining data from PPIs such as the HINT database or STRING database. (B) The 30 hub nodes obtained by using the Maximum Clique Centrality method. (C) The extended network obtained by extending the ACE2 associated drug network with the HINT database. Peacock blue color node is ACE2. Red node indicates the drug targeted by ACE2 protein. Light blue node indicates the protein that interacts with ACE2 in the HINT database, and the light yellow node indicates the extended drug that targets light blue node.