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. 2021 May 24;11:10763. doi: 10.1038/s41598-021-89578-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of immune cell infiltration based on RNA-seq data by using Immune Infiltration module. (A) Comparison of immune infiltration between SARS-CoV-2-positive and -negative samples in GSE152075 nasopharyngeal swabs. Most of the immune cells increased during infection. (B) The difference of immune infiltrating cells between the subjects entering and not entering ICU, using GSE157103 peripheral blood leukocyte samples. (C) The population characteristics of all subjects in the GSE157103 dataset. The age of samples was not significantly correlated with whether the samples were admitted to the ICU (chi-square test p-value = 0.087). However, compared to Figure S3 (Old vs. Young), the change in immune infiltration was in line with figure (B).