Figure 2.

Using titer to stratify patients with cPRA > 99.9%. This stratification was based on the first replicate from the baseline sample. The heat map shows the cPRA obtained from positive antibody specificities per titer for each of the 20 patients. The patients were ordered to show patients who would be the most likely to respond to desensitization (top) to least likely to respond to desensitization (bottom). For example, P2 continued to have a 100% cPRA when serum was diluted 1:4096, and thus it may be extremely difficult to remove enough antibodies to render this patient transplantable. Used with Permission. Tambur et al. Estimating Alloantibody levels in highly sensitized renal allograft candidates: Using serial dilutions to demonstrate a treatment effect in clinical trials. American Journal of Transplantation December 11, 2020 (55).