Table 3.
Uni- and multi-variate analysis of the number of cycles and other baseline variables as potential predictors of complete response.
| Variable | Complete pathologic response | |||||
|---|---|---|---|---|---|---|
| Univariate | Multivariate | |||||
| OR | 95% CI | p-value | aOR | 95% CI | p-value | |
| Number of cycles | 0.97 | 0.46, 1.96 | 0.941 | – | – | – |
| Clinical T stage | ||||||
| <=2 | Reference | – | Reference | |||
| >=3 | 1.47 | 0.77, 2.78 | 0.243 | – | – | – |
| Sex | ||||||
| Male | Reference | – | Reference | |||
| Female | 0.75 | 0.29, 1.73 | 0.512 | – | – | – |
| Age | 0.98 | 0.95, 1.01 | 0.158 | – | – | – |
| Ecog | 0.81 | 0.53, 1.16 | 0.254 | – | – | – |
| Charlson index | 0.96 | 0.81, 1.13 | 0.648 | – | – | – |
| HB (g/dl) | 1.00 | 0.98, 1.02 | 0.647 | – | – | – |
| Creatinine (mg/dl) | 0.80 | 0.39, 1.36 | 0.460 | – | – | – |
| PCR (mg/L) | 1.00 | 0.96, 1.03 | 0.931 | – | – | – |
| VES (mm/h) | 0.98 | 0.95, 1.00 | 0.043 | 0.98 | 0.95, 1.00 | 0.084 |
| NLR | 0.93 | 0.75, 1.12 | 0.450 | – | – | – |
| Neutrophils x10^3/µL | 1.01 | 0.97, 1.04 | 0.519 | – | – | – |
| Lymphocytes x10^3/µL | 1.05 | 0.94, 1.17 | 0.364 | – | – | – |
| Monocytes x10^3/µL | 1.30 | 1.06, 1.62 | 0.012 | 1.28 | 1.04, 1.58 | 0.019 |
| Eosinophils x10^3/µL | 1.03 | 0.42, 1.87 | 0.932 | – | – | – |
| Basophils x10^3/µL | 0.19 | 0.00, 64.7 | 0.599 | – | – | – |
| Platelets x10^3/µL | 1.00 | 1.00, 1.00 | 0.499 | – | – | – |
| Albumin (g/dl) | 1.13 | 0.61, 2.10 | 0.703 | – | – | – |
| BMI | 1.05 | 0.96, 1.15 | 0.269 | – | – | – |
| Total cholesterol level (mg/dl) | 1.00 | 1.00, 1.01 | 0.281 | – | – | – |
| HDL (mg/dl) | 1.00 | 0.97, 1.02 | 0.709 | – | – | – |
| Fibrinogen level (mg/dl) | 0.91 | 0.69, 1.18 | 0.491 | – | – | – |
| Preoperative PCR (mg/L) | 0.99 | 0.94, 1.04 | 0.719 | – | – | – |
P-values and OR are computed with single and multiple logistic regression. Significant values are highlighted in bold.