Table 4.

Uni- and multi-variate analysis of the number of cycles and other baseline variables as potential predictors of overall survival.

Variable	Overall survival
	Univariate			Multivariate
	HR	95% CI	p-value	aHR	95% CI	p-value
Number of cycles
3	Reference	–	Reference	Reference	–	Reference
4	1.63	0.99, 2.69	0.061	1.66	0.99, 2.80	0.056
Clinical T stage
<=2	Reference	–	Reference
>=3	0.85	0.52, 1.41	0.532	–	–	–
Sex
Male	Reference	–	Reference	–	–	–
Female	1.57	0.90, 2.76	0.129	–	–	–
Age	0.97	0.73, 1.28	0.811	–	–	–
Ecog	0.97	0.85, 1.11	0.644	–	–	–
Charlson index	1.00	0.98, 1.02	0.992	–	–	–
HB (g/dl)	0.65	0.37, 1.14	0.083	1.00	0.98, 1.02	0.968
Creatinine (mg/dl)	1.02	0.99, 1.04	0.250	–	–	–
PCR (mg/L)	1.02	1.00, 1.03	0.013	1.01	0.99, 1.03	0.374
VES (mm/h)	1.25	1.10, 1.42	0.001	1.01	1.00, 1.03	0.142
NLR	1.03	1.01, 1.05	0.011	1.16	1.01, 1.34	0.040
Neutrophils x10^3/µL	1.04	0.96, 1.12	0.397	–	–	–
Lymphocytes x10^3/µL	1.06	0.90, 1.25	0.514	–	–	–
Monocytes x10^3/µL	1.55	1.15, 2.07	0.030	1.12	0.96, 1.32	0.160
Eosinophils x10^3/µL	0.78	0.01, 70.9	0.915	–	–	–
Basophils x10^3/µL	1.00	1.00, 1.00	0.688	–	–	–
Platelets x10^3/µL	0.63	0.39, 1.00	0.050	1.00	1.00, 1.00	0.641
Albumin (g/dl)	0.91	0.85, 0.98	0.007	0.68	0.42, 1.12	0.131
BMI	1.01	1.01, 1.02	<0.001	0.95	0.88, 1.03	0.187
Total cholesterol level (mg/dl)	1.01	0.99, 1.02	0.401	–	–	–
HDL (mg/dl)	0.89	0.73, 1.10	0.276	–	–	–
Fibrinogen level (mg/dl)	1.00	0.97, 1.04	0.973	–	–	–
Preoperative PCR (mg/L)	1.00	0.97, 1.02	0.766	–	–	–

P-values and HR are computed with single and multiple Cox regression. Significant values are highlighted in bold.