Table 5.

Uni- and multi-variate analysis of the number of cycles and other baseline variable as potential predictors of cancer-specific survival.

Variable	Cancer specific survival
	Univariate			Multivariate
	HR	95% CI	p-value	aHR	95% CI	p-value
Number of cycles
3	Reference	–	Reference	Reference	–	Reference
4	1.28	0.70, 2.36	0.428	1.14	0.59, 2.20	0.690
Clinical T stage
<=2	Reference	–	Reference
>=3	0.81	0.45, 1.46	0.485	–	–	–
Sex
Male	Reference	–	Reference
Female	1.28	0.64, 2.56	0.499	–	–	–
Age	0.99	0.96, 1.02	0.628	–	–	–
Ecog	1.02	0.75, 1.40	0.888	–	–	–
Charlson index	1.05	0.92, 1.22	0.470	–	–	–
HB (g/dl)	1.00	0.98, 1.02	0.756	–	–	–
Creatinine (mg/dl)	0.44	0.20, 0.99	0.018	0.56	0.23, 1.34	0.194
PCR (mg/L)	1.02	0.99, 1.05	0.184	–	–	–
VES (mm/h)	1.03	1.01, 1.04	0.002	1.01	0.99, 1.03	0.339
NLR	1.34	1.17, 1.54	<0.001	1.07	0.89, 1.30	0.462
Neutrophils x10^3/µL	1.04	1.02, 1.05	0.002	1.02	0.99, 1.04	0209
Lymphocytes x10^3/µL	1.06	0.99, 1.13	0.179	–	–	–
Monocytes x10^3/µL	1.15	0.98, 1.35	0.129	–	–	–
Eosinophils x10^3/µL	1.66	1.24, 2.22	0.014	1.20	0.79, 1.84	0.397
Basophils x10^3/µL	1.23	0.01, 205	0.937	–	–	–
Platelets x10^3/µL	1.00	1.00, 1.00	0.181	–	–	–
Albumin (g/dl)	0.54	0.32, 0.94	0.030	0.64	0.34, 1.19	0.160
BMI	0.92	0.85, 1.00	0.045	0.94	0.85, 1.03	0.202
Total cholesterol level (mg/dl)	1.02	1.01, 1.03	<0.001	1.02	1.01, 1.02	<0.001
HDL (mg/dl)	1.00	0.98, 1.02	0.852	–	–	–
Fibrinogen level (mg/dl)	1.00	0.80, 1.26	0.972	–	–	–
Preoperative PCR (mg/L)	1.00	0.96, 1.04	0.993	–	–	–

P-values and HR are computed with single and multiple Cox regression. Significant values are highlighted in bold.