Table 3.
Diagnostic accuracies of differential metabolites between the ASD and control groups.
| Metabolites | AUC | Cut-off | Sensitivity (%) | Specificity (%) | FNR (%) | FPR (%) | PPV (%) | NPV (%) | LR+ | LR– |
|---|---|---|---|---|---|---|---|---|---|---|
| 3-Aminoisobutanoic acid | 0.568 | 0.5890 | 67.52 | 50.42 | 32.48 | 49.58 | 57.2 | 61.2 | 1.36 | 0.64 |
| Alanine | 0.508 | 0.4190 | 73.50 | 31.93 | 26.50 | 68.07 | 51.5 | 55.1 | 1.08 | 0.83 |
| Taurine | 0.502 | 0.5683 | 44.44 | 61.34 | 55.56 | 38.66 | 53.1 | 52.9 | 1.15 | 0.91 |
| Glycine | 0.560 | 1.2698 | 41.88 | 70.59 | 58.12 | 29.41 | 58.3 | 55.3 | 1.42 | 0.82 |
| Guanidinoacetic acid | 0.574 | 1.2573 | 76.07 | 40.34 | 23.93 | 59.66 | 55.6 | 63.2 | 1.27 | 0.59 |
| Creatine | 0.623 | 1.8805 | 44.44 | 77.31 | 55.56 | 22.69 | 65.8 | 58.6 | 1.96 | 0.72 |
| Creatinine | 0.639 | 4.6505 | 55.56 | 69.75 | 44.44 | 30.25 | 64.4 | 61.5 | 1.84 | 0.64 |
| Hydroxyphenylacetylglycine | 0.504 | 0.1710 | 26.50 | 78.99 | 73.50 | 21.01 | 55.4 | 52.2 | 1.26 | 0.93 |
| Phenylacetylglycine | 0.571 | 0.2742 | 87.18 | 26.89 | 12.82 | 73.11 | 54.0 | 68.1 | 1.19 | 0.48 |
| Hypoxanthine | 0.657 | 0.0359 | 88.03 | 36.13 | 11.97 | 63.87 | 57.5 | 75.4 | 1.38 | 0.33 |
| Formate | 0.529 | 0.0768 | 19.66 | 91.60 | 80.34 | 8.40 | 69.7 | 53.7 | 2.34 | 0.88 |
| N-methylnicotinamide | 0.595 | 0.0104 | 74.36 | 49.58 | 25.64 | 50.42 | 59.2 | 66.3 | 1.47 | 0.52 |
AUC, area under the curve; FNR, false-negative rate; FPR, false-positive rate; PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio positive; and LR–, likelihood ratio negative.