Table 1.

AUC and diagnostic value of different biomarkers for predicting LST.

		AUC	95% CI		Sensitivity	Specificity	Youden Index
Detection LST from HC	ETBF	0.795	0.735	0.855	0.752	0.797	0.549
	Ps	0.887	0.842	0.931	0.936	0.726	0.661
	Pm	0.842	0.790	0.893	0.706	0.850	0.556
	ETBF+Ps	0.904	0.864	0.944	0.899	0.788	0.687
	ETBF+Pm	0.880	0.835	0.925	0.844	0.823	0.667
	Ps+Pm	0.909	0.871	0.947	0.862	0.814	0.677
	ETBF+Ps+Pm	0.922	0.887	0.958	0.881	0.814	0.695
Detection LST from CRA	ETBF	0.645	0.584	0.707	0.725	0.620	0.345
	Ps	0.807	0.760	0.854	0.844	0.678	0.522
	Pm	0.787	0.735	0.840	0.706	0.769	0.476
	ETBF+Ps	0.808	0.761	0.855	0.835	0.688	0.522
	ETBF+Pm	0.791	0.739	0.842	0.633	0.841	0.474
	Ps+Pm	0.835	0.790	0.879	0.762	0.808	0.569
	ETBF+Ps+Pm	0.835	0.790	0.879	0.762	0.808	0.569

HC, healthy control; CRA, colorectal adenoma; LST, laterally spreading tumor; ETBF, Enterotoxigenic Bacteroides fragilis; Ps, Peptostreptococcus stomatis; Pm, Parvimonas micra.