TABLE 1.
The GO functional enrichment analyses of DEGs ranked by count.
| Term | Count | Genes | P-value |
| GO-BPs | |||
| GO:0006955∼immune response | 23 | ADAMDEC1, CXCL8, GZMA, GPR65, AQP9, C5AR1, PRG4, PPBP, CXCL13, CXCL5, JCHAIN, FCGR3A, FCGR3B, CCL8, IGKC, TRBC1, CTSG, IGLC1, PKHD1L1, CCL19, IL7R, CCL18, and FCGR1B | 1.08E-12 |
| GO:0007165∼signal transduction | 17 | CXCL8, TNFAIP6, C5AR1, TRHDE, RASGRP1, CXCL5, ADRA2A, GREM1, CCL8, PLAU, WIF1, KIT, CLEC5A, NDP, IL7R, CCL18, and S100A9 | 0.016322305 |
| GO:0006954∼inflammatory response | 16 | CXCL8, TNFAIP6, C5AR1, LY86, PPBP, CXCL13, CXCL5, CCL8, KIT, SPP1, CHI3L1, CCL19, CCL18, S100A9, SCG2, and S100A8 | 2.20E-07 |
| GO:0006508∼proteolysis | 15 | FCN1, CPA3, ADAMDEC1, TPSB2, MMP1, TRHDE, MMP9, MMP12, GZMK, MMP13, RELN, IGKC, PLAU, CTSG, and IGLC1 | 3.05E-05 |
| GO:0045087∼innate immune response | 11 | IGHM, C6, FCER1G, IGKC, CLEC5A, LY86, IGLC1, TREM1, S100A9, S100A8, and JCHAIN | 0.001788216 |
| GO:0006915∼apoptotic process | 11 | CD2, SHC4, GREM1, GZMA, GPR65, C5AR1, LY86, GZMB, CHI3L1, S100A9, and S100A8 | 0.012113741 |
| GO-CCs | |||
| GO:0005886∼plasma membrane | 48 | SHC4, GPM6A, IGHM, GPR65, C5AR1, AQP9, C2ORF88, GPR83, ATP1A2, GPR84, IFI30, TREM1, RASGRP1, CXCL16, FCGR3A, RELN, FCGR3B, IGKC, PRKAR2B, PLAU, LAMP3, TRBC1, CLEC5A, HMOX1, SCN7A, IGLC1, CTSG, FCGR1B, PRIMA1, FCER1G, VCAM1, CD93, ANXA3, LY86, SLC16A10, ADRA2A, VMP1, CD2, VNN2, KIT, GPR160, PCDHB5, PLPP3, IL7R, STEAP1, S100A9, S100A8, and CLEC4G | 8.05E-04 |
| GO:0005576∼extracellular region | 46 | FCN1, ADAMDEC1, TPSB2, CXCL8, COL11A1, TNC, NDNF, CXCL13, IFI30, THBS2, TREM1, PLA2G7, CHRDL1, CXCL5, CXCL16, JCHAIN, APELA, C6, IBSP, IGKC, PLAU, WIF1, SPP1, COL10A1, IGLC1, CTSG, CCL19, PLTP, CPA3, CHST9, MMP1, GZMA, ADIPOQ, PRG4, PPBP, MMP9, MFAP5, CD2, MMP12, GZMK, IGSF10, MMP13, COL6A6, IL7R, S100A9, and S100A8 | 1.19E-15 |
| GO:0005615∼extracellular space | 41 | IGHM, CXCL8, TNFAIP6, TNC, CXCL13, CHRDL2, CXCL5, CXCL16, JCHAIN, APELA, RELN, CCL8, IBSP, IGKC, PLAU, SPP1, HMOX1, IGLC1, CTSG, NDP, CCL19, CCL18, PLTP, TIMP4, CTHRC1, CPA3, VCAM1, MYOC, ADIPOQ, LY86, PPBP, MMP9, GREM1, MMP13, KIT, CHI3L1, PKHD1L1, S100A9, SCG2, S100A8, and ANGPTL1 | 1.04E-14 |
| GO:0070062∼extracellular exosome | 31 | GPM6A, IGHM, ITLN1, TRHDE, COCH, JCHAIN, FCGR3A, C6, FCGR3B, ALDH2, IGKC, TSPAN8, PRKAR2B, PLAU, SPP1, ACP5, IGLC1, CTSG, VCAM1, MYOC, ANXA3, ADIPOQ, MMP9, KRT18, KRT14, CHI3L1, MNDA, PLPP3, S100A9, S100A8, and ANGPTL1 | 0.022687598 |
| GO:0005887∼integral component of plasma membrane | 17 | CD52, FCER1G, SCARA5, GPR65, AQP9, C5AR1, LAPTM5, GPR83, SLC16A10, GPR84, TRHDE, ADRA2A, CD2, TSPAN8, CLEC5A, PLPP3, and STEAP1 | 0.059028895 |
| GO:0005578∼proteinaceous extracellular matrix | 14 | MYOC, MMP1, COL11A1, NDNF, MMP9, COCH, MMP12, MMP13, RELN, COL10A1, CHI3L1, COL6A6, TIMP4, and CTHRC1 | 9.98E-08 |
| GO-MFs | |||
| GO:0004252∼serine-type endopeptidase activity | 13 | FCN1, TPSB2, MMP1, GZMA, GZMB, MMP9, MMP12, GZMK, MMP13, IGKC, PLAU, CTSG, and IGLC1 | 3.25E-07 |
| GO:0042803∼protein homodimerization activity | 11 | CD2, BCL2A1, GZMA, ID1, KIT, ADIPOQ, HMOX1, NDP, RASGRP1, ADRA2A, and JCHAIN | 0.038761584 |
| GO:0005509∼calcium ion binding | 10 | MMP12, MMP13, CD93, ANXA3, MMP1, PCDHB5, THBS2, S100A9, RASGRP1, and S100A8 | 0.075449087 |
| GO:0008009∼chemokine activity | 8 | CCL8, CXCL8, PPBP, CCL19, CXCL13, CCL18, CXCL5, and CXCL16 | 5.78E-08 |
| GO:0003823∼antigen binding | 5 | IGHM, IGKC, IGLC1, IL7R, and JCHAIN | 0.006624345 |
| GO:0004222∼metalloendopeptidase activity | 5 | MMP12, ADAMDEC1, MMP13, MMP1, and MMP9 | 0.009131648 |