Table 1.

Summary of different subtypes of placenta-derived extracellular vesicles.

	Exosomes	Microvesicles	Apoptotic bodies	Syncytial nuclear aggregates (SNA)
Size	30nm ~ 200nm	200nm ~ 1μm	1μm ~ 5μm	20μ-200μm
Origin	Endocytic pathway	Plasma membrane	Plasma membrane	Syncytiotrophoblast
Function	Intercellular communication	Intercellular communication	Facilitate phagocytosis	Unclear
Contents	Proteins, miRNA, mRNA, lipid and metabolites	Proteins, miRNA, mRNA, lipid and metabolites	Nuclear fractions, cellular organelles	Nucleus, proteins, miRNA, mRNA, lipid, metabolites
Markers	Alix, CD81, CD63, CD9	Integrins, selectins, CD40	Annexin V, phosphatidylserine	Nucleus cluster