Table 2.
Reproductive performance of immunodeficient mouse model.
| Immune cell deficiency | Innate immune cell depletion | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cell types | Nude | SCID | Nod-SCID | Rag-/- | Rag-/- γc-/- | Treg-/- | Csf1-null | CD11b+ | MDSC |
| Mature B cells | Present | Absent | Absent | Absent | Absent | Present | Present | Present | Present |
| Mature T cells | Absent | Absent | Absent | Absent | Absent | Present | Present | Present | Present |
| Dendritic cells | Present | Present | Defective | Present | Present | Present | Present | Present | Present |
| NK cells | Present | Present | Defective | Present | Present | Present | Present | Present | Present |
| Treg | N/A | N/A | N/A | N/A | N/A | Absent | Present | Present | Present |
| Macrophages | Present | Present | Present | Present | Present | Present | Absent | Absent | Absent |
| Monocytes | Present | Present | Present | Present | Present | Present | Defective | Absent | Defective |
| MDSC | N/A | N/A | N/A | N/A | N/A | Present | N/A | N/A | Absent |
| Reproductivity | Fertile | Fertile | Impaired | Fertile | Fertile | Impaired | Infertile | Infertile | Impaired |
| Reference | (86) | (87) | (88, 89) | (90) | (91) | (92) | (93, 94) | (95) | (96) |
MDSC, myeloid-derived suppressor cells.