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. 2021 May 11;12:672433. doi: 10.3389/fgene.2021.672433

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Copyright © 2021 Le Roy, Stapane, Gautron and Hincke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple alignment of OC-116/MEPE proteins in tetrapods. The alignment was built with ClustalW (www.phylogeny.fr) and edited with Jalview v2.11.1.4 (https://www.jalview.org/). Gray colors of letters correspond to percentage of identity (dark gray > 80% identity, medium gray > 60% identity, and light gray > 40% identity). The dentonin region identified in human MEPE, and regions with amino acid consensus in birds, are, respectively, framed in red and blue. Putative phosphorylated sites of the ASARM (acidic, serine, and aspartic acid-rich motif) peptide are indicated by green dots above the alignment. Sequences aligned are from Gallus gallus (AAF00982.3), Coturnix japonica (XP_015716951.1), Numida meleagris (XP_021251779.1), Taeniopygia guttata (XP_030127798.1), Apteryx rowi (XP_025920573.1), Alligator mississippiensis (XP_019343676.1), Python bivittatus (XP_025029286.1), Podarcis muralis (XP_028598766.1), Homo sapiens (XP_006714341.1), Monodelphis domestica (XP_007495981.1), and Xenopus tropicalis (XP_002938672.2).