FIGURE 9.

Synteny of OC17-like, XCA and REG orthologs and paralogs in birds and its relatives in vertebrates. OC17-like/XCA2 is represented by a dark orange box and XCA1 by a light orange box. REG4 (regenerating Islet-derived protein 4) is represented by a yellow box and REG1 A and B (Lithostathine) are represented by a brown box. Flanking genes are represented by gray boxes: lipase maturation factor 2 (LMF2), condensing-2 complex subunit H2 (NCAPH2), thymidine phosphorylase (TYMP), outer dense fiber protein 3B (ODF3B), carnitine O-palmitoyltransferase 1 (CPT1B), choline/ethanolamine kinase (CHKB), vesicle-trafficking protein (SCE22B), neurogenic locus notch homolog protein 2 (NOTCH2), hydroxymethylglutaryl-CoA synthase (HMGCS2) and D-3-phosphoglycerate dehydrogenase (PHGDH). Gene IDs are listed in Supplementary Table 2. The left part of the figure depicts the phylogenetic relationship between vertebrate species (adapted from www.tolweb.org and Kapusta et al., 2017).