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. 2021 May 20;44:102016. doi: 10.1016/j.redox.2021.102016

Fig. 4.

Fig. 4

A) Representative images of B- and M-mode in vivo echocardiographic assessment of cardiac function in CARNS1−/− rats and WT controls. B-G) Isovolumetric contraction time (IVCT - ES: −1.26), systolic perfusion velocity (S'- ES: 1.01), left ventricle ejection fraction (LVEF % - ES: 1.27) and left ventricle shortening fraction (% LVSF – ES: 1.28) (WT: n = 8, CARNS1−/−: n = 10), end systolic volume and cardiac output adjusted by body mass (WT: n = 4, CARNS1−/−: n = 7; ES: −1.42). H-J) Resting heart rate measured during electrocardiogram (WT: n = 7, CARNS1−/−: n = 7; ES: −1.16), left ventricular systolic and diastolic diameter adjusted by body mass (WT: n = 4, CARNS1−/−: n = 7; ES: −2.32 and −1.86, respectively). K-L) Representative images of total collagen positive signal in the cardiac tissue and density plot of total collagen quantification in the WT (n = 5) and CARNS1−/− (n = 5) groups (Kolmogorov-Smirnov test for between-genotype differences in distributions – ES: −0.03). M-N) E/e’ ratio (ES: −1.20) and cardiac performance index (TEI - ES: −1.06) (WT: n = 8, CARNS1−/−: n = 10); O-Q) ST-wave amplitude (ES: −1.39), T-wave amplitude (ES: −2.26) and QTc interval (ES: −1.83), (WT: n = 7, CARNS1−/−: n = 7). All p-values displayed in the dot plots refer to Welch two-sample t-tests.