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. 2021 May 18;16:3457–3472. doi: 10.2147/IJN.S306269

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© 2021 Zhang et al.

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In vivo antitumor efficiency of A375 toward tumor-bearing BALB/c mice model. (A) The mice were intratumorally treated with (1) PBS + Laser; (2) MSN(Mn)-ICG/DTIC; (3) MSN(Mn)-ICG + Laser; (4) DTIC; or (5) MSN(Mn)-ICG/DTIC + Laser (808 nm, 0.75 W/cm², 10 min); (B) images of tumors stripped from mice after different treatments; (C) tumor volume growth curves with different treatments; (D) relative tumor volume; (E) TGI after treatment; (F) body weight changes of different groups; (G) H&E stain analysis of tumor sections after different treatments (**p < 0.01; ***p < 0.001).