. 2021 Mar 11;8(2):57–67. doi: 10.1016/j.ijpam.2021.03.001

Table 3.

List of the preferred empiric antibiotic agents and alternative for infants and children with community-acquired UTI.

Age	Treatment sitting	Empirical therapy		Duration of treatment
Age	Treatment sitting	First line (one of the following)	Alternative^a	Duration of treatment
≥3 months – 14 Years	Outpatient	Amoxicillin-clavulanic acid	Cefixime	3–7 days
		Cephalexin
		Cefuroxime
		Cefprozil
	Inpatient^a	Ceftriaxone	Gentamycin^b +/-Ceftriaxone^c	7–14 days

Check any previous urine culture and susceptibility results and choose antibiotics accordingly.

Alternative: If no improvement of fever and UTI symptoms at least 48 h after starting the first choice or when first choice not suitable.

Gentamicin should be considered in children with previous UTI caused by ESBL-producing bacteria and in those who have been recently exposed to cephalosporin antibiotic treatment during the last 3 months.

Broader or combined antimicrobial therapy of ceftriaxone and aminoglycoside may be indicated in critically ill patients and in those whose clinical condition worsens after starting the first-line antimicrobial therapy.