Figure 1.
The schematic diagram of bell-shaped effects of the exogenous and endogenous H2S on cancer. In short, endogenous or low concentrations of exogenous H2S promotes cancer growth by stimulating angiogenesis, and promoting cell proliferation and metastasis. Inhibition of endogenous H2S production or high-dose exogenous H2S administration enables cancer cell death through inhibiting proliferation, inducing apoptosis and DNA damage, and arresting cell cycle. The models suggest that the inhibitors of H2S biosynthetic enzymes and H2S donors represent two strategies to treat cancer.