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. 2020 Dec 15;11(5):1083–1097. doi: 10.1016/j.apsb.2020.12.011

Figure 2.

Figure 2

Pivotal ICPs in PCa and their interaction with specific ligand. The interaction of negative ICPs, including PD-1, CTLA-4, LAG-3, with their specific ligand were shown in detail. Interplay of PD-L2 on the TME with B cells and NK cells and PD-L1 and CTLA-4 on the TME with T cell through their specific ligand activates the immunosuppression and causes tumor immune evasion. Overexpressed LAG-3 on all of B cells, NK cells and T cell deactivates DC and MQ functions which result in tumor-induced immunosuppression.