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. 2020 Dec 15;11(5):1175–1199. doi: 10.1016/j.apsb.2020.12.004

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© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

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(A) Schematic representation of aptamer-functionalized Ag NCs-assisted siRNA delivery and tracking for type-specific cells. Reprinted with permission from Ref. 186. Copyright © 2013, the Royal Society of Chemistry. (B) Schematic illustration of the synthesis of Cd NCs, doxorubicin (DOX) loading into the HA-Cd NC nanocarrier (DOX-HA-Cd NCs), and HA receptor-directed targeted drug delivery. Reprinted with permission from Ref. 188. Copyright © 2016, Tsinghua University Press. (C) Schematic illustration of the delivery mechanism of Au NCs-siRNA complex for NGF silencing and pancreatic cancer therapy. The Au NCs-siRNA complex protected the NGF siRNA from serum nuclease degradation and renal clearance, thus enhancing the accumulation of NGF siRNA in tumor cells. Reprinted with permission from Ref. 189. Copyright © 2017, Nature Publishing Group.