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Effect of ammonium hexafluorophosphate as additive on the addition reactions of arylboronic acids to 3-methyl-2-cyclohexanone catalysed by L9/Pd(TFA)2 [48,50].
 | ||||||
| 60 °C, without additive | 40 °C, 30 mol % NH4PF6, 5 equiv H2O | |||||
| Ar | entry | yield (%) | ee (%) | entry | yield (%) | ee (%) |
| 3-Cl-C6H4 | 1 | 55 | 97 | 6 | 96 | 96 |
| 4-Cl-C6H4 | 2 | 94 | 95 | 7a | 87–91 | 93 |
| 3-Br-C6H4 | 3 | 44 | 86 | 8 | 84 | 84 |
| 3-NO2-C6H4 | 4 | 40 | 92 | 9 | 81 | 91 |
| 2-F-C6H4 | 5 | 32 | 77 | 10 | 70 | 77 |
aReaction performed at a 35 mmol scale [50].
