Table 1. Characteristics of Included Trials.
| Characteristic | No. (%)a | Trials with any results reported, No. (%) |
|---|---|---|
| No. | 12 240 | NA |
| Registration before participant enrollment | ||
| No | 5282 (43.2) | 2902 (54.9) |
| Yes | 6951 (56.8) | 4519 (65.0) |
| Phase | ||
| 0-1 | 3327 (27.2) | 1416 (42.6) |
| 1/2-2 | 6270 (51.2) | 4352 (69.4) |
| 2/3-3 | 1297 (10.6) | 939 (72.4) |
| 4 | 342 (2.8) | 195 (57.0) |
| NAb | 1004 (8.2) | 523 (52.1) |
| No. of groups | ||
| 1 | 7140 (59.2) | 4183 (58.6) |
| 2 | 3699 (30.6) | 2441 (66.0) |
| ≥3 | 1231 (10.2) | 749 (60.8) |
| Treatment randomization | ||
| Nonrandomized | 8337 (69.1) | 4906 (58.8) |
| Randomized | 3735 (30.9) | 2450 (65.7) |
| Blinding | ||
| Open label | 10 854 (88.7) | 6490 (59.8) |
| Any blinding | 1386 (11.3) | 935 (67.5) |
| Total enrollment, No. of patients | ||
| ≤50 | 7898 (64.6) | 4395 (55.6) |
| 51-100 | 2098 (17.2) | 1360 (64.8) |
| >100 | 2224 (18.2) | 1659 (74.6) |
| With US study site | ||
| No | 4499 (38.3) | 2348 (52.2) |
| Yes | 7242 (61.7) | 4807 (66.4) |
| Funding source | ||
| Industry | 6421 (52.5) | 4142 (64.5) |
| NIH | 1423 (11.6) | 982 (69.0) |
| Other academic or nonprofit organizations | 4396 (35.9) | 2301 (52.3) |
| Recruitment status | ||
| Completed | 9363 (76.5) | 5758 (61.5) |
| Terminated | 2977 (23.5) | 1667 (57.9) |
Abbreviations: NA, not applicable; NIH, National Institutes of Health.
a
The number of trials with available data might be different for different characteristics.
b
Including trials of devices and behavioral interventions.