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. 2021 May 20;46(1):134. doi: 10.3892/or.2021.8085

Figure 4.

Figure 4.

PCED1B-AS1 functions as a ceRNA of miR-411-3p to regulate HIF-1α expression. (A) Binding sequence between the HIF-1α 3′UTR and miR-411-3p was predicted using bioinformatics. (B) Dual luciferase reporter assays showed that miR-411-3p targeted the HIF-1α 3′-UTR. (C) Analysis of the expression of HIF-1α in PDAC tissues in the GEPIA database. (D) Relative expression levels of miR-411-3p in the 47 PDAC tissues and corresponding non-tumor tissues were detected using RT-qPCR. (E) Correlation between the HIF-1α expression and PCED1B-AS1 expression in clinical samples was analyzed using Pearson's correlation analysis. ***P<0.001. ceRNA, competing endogenous RNA; miR, microRNA; HIF-1α, hypoxia inducible factor-1α; UTR, untranslated region; PDAC, pancreatic ductal adenocarcinoma; GEPIA, Gene Expression Profiling Interactive Analysis; PCED1B-AS1, PC-esterase domain containing 1B-antisense RNA 1.