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. 2021 May 20;46(1):134. doi: 10.3892/or.2021.8085

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Figure 5. — PCED1B-AS1 modulates the biological behaviors of PDAC cells via regulation of a miR-411-3p/HIF-1α axis. (A) Western blotting was used to detect the expression of HIF-1α expression in CFPAC-1 and SW1990 cells transfected with si-NC, si-PCED1B-AS1, si-PCED1B-AS1 + miR-411-3p inhibitor or si-PCED1B-AS1 + HIF-1α overexpression plasmid. (B-E) Proliferation, invasion and expression of EMT markers in CFPAC-1 and SW1990 cells were detected using a CCK-8 assay, EdU assay, Transwell invasion assay and western blotting, respectively. *P<0.05, **P<0.01, ***P<0.001. siRNA, small interfering RNA; si-NC, si-negative control; PDAC, pancreatic ductal adenocarcinoma; PCED1B-AS1, PC-esterase domain containing 1B-antisense RNA 1; miR, microRNA; HIF-1α, hypoxia inducible factor-1α; CCK-8, Cell Counting Kit-8.