FIGURE 6.

Delayed onset of high‐fat diet (HFD) consumption until 3 and 6 months of age reduced cortical fibrinogen extravasation in 8‐ and 11‐month‐old Alzheimer's disease (AD) mice. A, C, Representative images of fibrinogen staining (red) show fibrinogen extravasation from collagen IV‐positive blood vessels (green) into the retrosplenial cortex (RSC) of (A) 8‐month‐old and (C) 11‐month‐old AD control (CON) mice, but not AD HFD mice. Scale bar = 20 μm. B, D, HFD significantly reduced fibrinogen staining outside of blood vessels in RSC of 8‐ and 11‐month‐old AD mice. n = 8 mice per group, three sections per animal. Results are from one independent experiment. Statistical analysis performed by Student's t‐test. **P < 0.01