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. 2021 May 21;218(7):e20191766. doi: 10.1084/jem.20191766

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© 2021 Tokuyama et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 1. — Human-specific envelope-coding ERV-K loci are elevated in lupus blood. ERVmap analysis of RNA-seq data from whole blood of healthy (n = 18) and SLE (n = 99) individuals was performed. (A) 113 significantly elevated ERV loci are depicted as a hierarchical cluster heatmap. (B) Spearman correlation between the sum of significantly elevated ERV read counts and levels of indicated clinical parameters. (C) Normalized read counts for ERV-K loci were compared between healthy and SLE samples. (D) Comparison of normalized ERV-K read counts between healthy (black), ISM low (blue), and ISM high (red) groups. Mann–Whitney t test was performed to calculate significance for C and D. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. dsDNA, double-stranded DNA.