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. 2021 Apr 23;10(5):486. doi: 10.3390/antibiotics10050486

Figure 3.

Figure 3

CFTR modulators. 1: transcription; 2: translation; 3: posttranslational modification; 4: protein trafficking; 5: surface expression of functional CFTR; 6: CFTR turnover. CFTR: cystic fibrosis transmembrane conductance regulator. NMD nonsense-mediated mRNA decay. The Roman numerals (I–VII) represent the different classes of CFTR mutations and the place where they originate, and therefore also the target of treatment. Adapted from Cuyx, De Boeck. Treating the Underlying CFTR defect in Patients with CF [168].