Table 3.

In vivo studies on the effects of some species belonging to the Valerianaceae sub-family on the Central Nervous System.

Compound/Species	Animal Model	Dosage	Outcomes	Ref.
Valerenic acid derivatives	Male mice (c57Bl/6N)	3 mg/kg	Anxiolytic effect	[151]
Valerenic acid derivatives	Mutant mice (GABAA receptor b3 subunit mutation)	From 1 to 30 mg/kg	Anxiolitic effects	[152]
V. glechomifolia	Swiss male CF1 mice	1, 3, and 10 mg/kg	Sedative effects	[149]
V. prionophylla	Swiss female mice; Wistar male rats	50, 100, and 150 mg/kg	Anxiolytic; antidepressant; hypno-sedative effects	[58]
N. chinensis	Different animal model	Different dosages	Antidepressant; anticonvulsant; neuroprotective and antiparkinson activities; cognition and memory improvement	[153]
V. jatamansi	Kunming mice	Ethanolic extract	Anxiolytic effects; No drug dependence	[146]
V. officinalis	Zebrafish larvae	0.3 g/kg, 0.9 g/kg	Regulation of neural-activity genes	[154]
V. officinalis	BALB/c mice	1, 2.5, 5, and 7 mg/mL	Modulate GABAA subunit β3 receptors; sedative effects	[155]
V. edulis	Wistar male rats	2.5 mg/10 g; 5 mg/10 g	Anticonvulsant properties	[156]