Table 1.
Characteristics of the NAFLD patients according to the PNPLA3 genotype.
| Variable | PNPLA3 | |||
|---|---|---|---|---|
| CC n = 30 |
CG n = 58 |
GG n = 52 |
p-Value | |
| HSD17B13, AA/AG, GG | 15/15 | 30/28 | 27/25 | 0.984 |
| Sex, female | 12 (40.0%) | 31 (53.4%) | 26 (50.0%) | 0.485 |
| Age, years | 54 (23–81) | 55 (19–75) | 60 (17–76) | 0.291 |
| BMI, kg/m2 | 28.3 (23.3–45.2) | 27.2 (20.8–44.0) | 26.4 (17.6–41.0) | 0.083 |
| Hypertension | 14 (46.7%) | 25 (43.1%) | 20 (38.5%) | 0.429 |
| Diabetes | 15 (50.0%) | 25 (43.1%) | 23 (44.2%) | 0.819 |
| Hyperlipidemia | 19 (63.3%) | 36 (62.1%) | 25 (48.1%) | 0.248 |
| Albumin, g/dL | 4.5 (3.8–5.0) | 4.5 (3.5–5.2) | 4.4 (3.7–5.0) | 0.825 |
| AST, IU/L | 32.5 (12–93) | 42.5 (18–162) | 47.5 (22–155) | 0.186 |
| ALT, IU/L | 46 (18–146) | 53.5 (19–233) | 56 (14–166) | 0.507 |
| GGT, IU/L | 71.5 (18–279) | 59 (14–533) | 59.5 (14–202) | 0.833 |
| Platelet count, ×103/μL | 239.5 (90–420) | 226.5 (81–377) | 213 (75–444) | 0.210 |
| Total cholesterol, mg/dL | 195.5 (148–347) | 205 (137–281) | 201 (94–311) | 0.548 |
| TG, mg/dL | 190 (55–721) | 142.5 (49–739) | 129 (53–644) | 0.039 |
| LDL–C, mg/dL | 116 (33–252) | 127 (59–219) | 115 (36–177) | 0.478 |
| HDL–C, mg/dL | 47 (21–67) | 55 (30–93) | 50 (29–96) | 0.015 |
| FPG, mg/dL | 112 (77–232) | 106.5 (76–172) | 112 (71–236) | 0.484 |
| HbA1c, % | 6.1 (5.2–11.2) | 6.0 (5.0–8.2) | 6.0 (5.2–8.7) | 0.396 |
| FIB-4 index | 1.10 (0.28–7.83) | 1.38 (0.33–6.43) | 1.40 (0.39–7.73) | 0.100 |
| CAP, dB/m | 323.5 (230–400) | 308.5 (232–400) | 299 (159–394) | 0.052 |
| LSM, kPa | 8.9 (3.3–27.0) | 8.6 (2.9–39.7) | 9.6 (3.5–46.4) | 0.778 |
| Fibrosis stage (0/1/2/3/4) | 15/9/4/2/0 | 19/23/6/5/5 | 18/13/7/10/4 | 0.276 |
Results are presented as n (%) for qualitative data or as medians for quantitative data. Abbreviations: PNPLA3, patatin-like phospholipase domain containing 3; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ–glutamyl transferase; TG, triglyceride; LDL–C, low-density lipoprotein cholesterol; HDL–C, high-density lipoprotein cholesterol; FPG, fasting plasma glucose; FIB-4 index, Fibrosis-4 index.