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Raster-scanning optoacoustic mesoscopy (RSOM) of murine paw vasculature and the potential imaging readouts for inflammation. (a) Shows the hemoglobin signal representing the vascular network, which can be used to identify changes in blood volume; (b) multi-wavelength illumination enables the separation of melanin and hemoglobin signals; (c) further unmixing enables the visualization of oxygenation status of hemoglobin. Scale bar indicates 1mm.
