Figure 14.

Design and concept of the sharp-edge-based acoustofluidic device for cell lysis utilized in [56]. (a) Schematic overview of the mechanism of the acoustofluidic lysis device. Sharp-edged structures are constructed on the sidewalls of the channels. (b) The device is composed of a serpentine channel with a large number of sharp-edged structures, an acoustic transducer, and a thin glass substrate. (c) Comparison of the cell density downstream and upstream of the channel. Image (d) upstream and (e) downstream the channel. Adapted with permission from [56]. Copyright 2019 Royal Society of Chemistry.