Fig. 4. Disease trajectories leading to mortality with different death causes among depression individuals.

This figure shows the identified disease trajectories leading to CVDD (Cardiovascular disease death), RSDD (Respiratory system disease death), and MND (Malignant neoplasm death) among depression individuals. The death causes are shown within the octagons. The combined ICD-10 codes for the medical conditions are shown within the circle and round rectangle. The color of the circle and octagon represents the hazard ratios of this medical condition when comparing depression individuals to matched individuals without depression. The number above the arrow connecting two circles and circle with octagon corresponds to the number of disease pairs among depression individuals. The color of the arrows indicates the odds ratio of the sequential association between the two medical conditions among depression individuals.