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. 2021 May 25;26(11):6736–6746. doi: 10.1038/s41380-021-01170-6

Table 2.

Hazard ratios (HRs) with 95% confidence intervals (CIs) of different causes of death among depression individuals compared to matched individuals without depression.

Cause of death Both sex (N = 24,130) Males (N = 8776) Females (N = 15,354)
Na HR (95% CI)b Na HR (95% CI)b Na HR (95% CI)b
Malignant neoplasms 851 2.17 (2.01–2.35) 400 2.25 (2.01–2.53) 451 2.12 (1.90–2.36)
Cardiovascular diseases 469 3.00 (2.69–3.36) 296 3.06 (2.66–3.53) 173 2.96 (2.46–3.56)
Respiratory system diseases 314 4.65 (4.00–5.41) 150 3.82 (3.09–4.71) 164 5.89 (4.72–7.34)
Neural system diseases 160 3.92 (3.20–4.81) 83 4.74 (3.54–6.35) 77 3.32 (2.49–4.42)
Digestive system diseases 152 4.25 (3.43–5.28) 93 4.39 (3.33–5.80) 59 4.10 (2.90–5.78)
Unnatural causes 129 6.42 (4.95–8.33) 74 5.72 (4.11–7.95) 55 7.85 (5.12–12.04)
Mental disorder diseases 99 5.63 (4.24–7.49) 57 6.13 (4.18–8.97) 42 5.13 (3.35–7.86)
Endocrine system diseases 53 3.99 (2.79–5.71) 28 3.80 (2.34–6.18) 25 4.28 (2.52–7.29)
Genitourinary system diseases 22 2.71 (1.62–4.53) 12 2.25 (1.14–4.42) 10 3.66 (1.63–8.23)
Infectious and parasitic diseases 21 3.02 (1.76–5.17) 12 3.15 (1.54–6.43) 9 2.89 (1.27–6.53)

This table shows numbers and the HRs with 95% CIs of 10 different causes of death with statistically significant HRs after Bonferroni correction and N ≥ 20 in all depression individuals, males and females.

aNumber of the depression individuals died with the corresponding underlying causes.

bHazard ratios (with 95% confidence intervals) of the causes of death in depression individuals compared to sex, Townsend deprivation index and year of birth matched individuals without depression.