Table 2.
Genotype, allele, and carrier frequencies of VEGF polymorphisms in ILD patients and controls included in this study.
| VEGF Polymorphism | Genotype/Allele/ Carriers |
Whole Cohort of ILD Patients % (n/N) |
Healthy Controls % (n/N) |
OR [95% CI] | p-Value |
|---|---|---|---|---|---|
| rs833061 | TT | 32.6 (142/435) | 28.8 (151/524) | Reference | - |
| TC | 47.6 (207/435) | 48.7 (255/524) | 0.86 [0.64–1.16] | 0.33 | |
| CC | 19.8 (86/435) | 22.5 (118/524) | 0.78 [0.54–1.11] | 0.17 | |
| T | 56.4 (491/870) | 53.1 (557/1048) | Reference | - | |
| C | 43.6 (379/870) | 46.9 (491/1048) | 0.88 [0.73–1.05] | 0.15 | |
| C non-carriers | 32.6 (142/435) | 28.8 (151/524) | Reference | - | |
| C carriers | 67.4 (293/435) | 71.2 (373/524) | 0.84 [0.63–1.10] | 0.20 | |
| rs1570360 | GG | 53.5 (232/434) | 48.3 (250/518) | Reference | - |
| GA | 38.0 (165/434) | 41.9 (217/518) | 0.82 [0.63–1.07] | 0.15 | |
| AA | 8.5 (37/434) | 9.8 (51/518) | 0.78 [0.49–1.24] | 0.29 | |
| G | 72.5 (629/868) | 69.2 (717/1036) | Reference | - | |
| A | 27.5 (239/868) | 30.8 (319/1036) | 0.85 [0.70–1.04] | 0.12 | |
| A non-carriers | 53.5 (232/434) | 48.3 (250/518) | Reference | - | |
| A carriers | 46.5 (202/434) | 51.7 (268/518) | 0.81 [0.63–1.05] | 0.11 | |
| rs2010963 | GG | 43.0 (187/435) | 43.7 (231/528) | Reference | - |
| GC | 43.2 (188/435) | 46.6 (246/528) | 0.94 [0.72–1.24] | 0.68 | |
| CC | 13.8 (60/435) | 9.7 (51/528) | 1.45 [0.95–2.21] | 0.08 | |
| G | 64.6 (562/870) | 67.0 (708/1056) | Reference | - | |
| C | 35.4 (308/870) | 33.0 (348/1056) | 1.11 [0.92–1.35] | 0.26 | |
| C non-carriers | 43.0 (187/435) | 43.7 (231/528) | Reference | - | |
| C carriers | 57.0 (248/435) | 56.3 (297/528) | 1.03 [0.80–1.33] | 0.81 | |
| rs3025020 | CC | 51.9 (225/434) | 54.4 (285/524) | Reference | - |
| CT | 39.6 (172/434) | 37.0 (194/524) | 1.12 [0.86–1.47] | 0.40 | |
| TT | 8.5 (37/434) | 8.6 (45/524) | 1.04 [0.65–1.66] | 0.87 | |
| C | 71.7 (622/868) | 72.9 (764/1048) | Reference | - | |
| T | 28.3 (246/868) | 27.1 (284/1048) | 1.06 [0.87–1.30] | 0.55 | |
| T non-carriers | 51.8 (225/434) | 54.4 (285/524) | Reference | - | |
| T carriers | 48.2 (209/434) | 45.6 (239/524) | 1.11 [0.86–1.43] | 0.43 | |
| rs3025039 | CC | 74.5 (325/436) | 79.0 (418/529) | Reference | - |
| CT | 22.7 (99/436) | 18.9 (100/529) | 1.27 [0.93–1.73] | 0.13 | |
| TT | 2.8 (12/436) | 2.1 (11/529) | 1.40 [0.61–3.22] | 0.42 | |
| C | 85.9 (749/872) | 88.5 (936/1058) | Reference | - | |
| T | 14.1 (123/872) | 11.5 (122/1058) | 1.26 [0.96–1.65] | 0.09 | |
| T non-carriers | 74.5 (325/436) | 79.0 (418/529) | Reference | - | |
| T carriers | 25.5 (111/436) | 21.0 (111/529) | 1.29 [0.95–1.74] | 0.10 |
CI: Confidence interval; ILD: Interstitial lung disease; N: Total number of individuals successfully genotyped; OR: Odds ratio; VEGF: Vascular endothelial growth factor.