Table 3.
Genotype, allele, and carrier frequencies of VEGF polymorphisms in IIP and non-IIP patients included in this study.
| VEGF Polymorphism | Genotype/Allele/ Carriers |
IIP Patients % (n/N) |
Non-IIP Patients % (n/N) |
OR [95% CI] * | p-Value * |
|---|---|---|---|---|---|
| rs833061 | TT | 28.7 (70/244) | 37.7 (72/191) | Reference | - |
| TC | 49.2 (120/244) | 45.6 (87/191) | 1.32 [0.82–2.11] | 0.25 | |
| CC | 22.1 (54/244) | 16.7 (32/191) | 1.73 [0.95–3.16] | 0.07 | |
| T | 53.3 (260/488) | 60.5 (231/382) | Reference | - | |
| C | 46.7 (228/488) | 39.5 (151/382) | 1.33 [0.99–1.79] | 0.06 | |
| C non-carriers | 28.7 (70/244) | 37.7 (72/191) | Reference | - | |
| C carriers | 71.3 (174/244) | 62.3 (119/191) | 1.43 [0.92–2.22] | 0.12 | |
| rs1570360 | GG | 47.5 (116/244) | 61.1 (116/190) | Reference | - |
| GA | 43.4 (106/244) | 31.1 (59/190) | 1.79 [1.14–2.81] | 0.01 | |
| AA | 9.1 (22/244) | 7.8 (15/190) | 1.50 [0.68–3.31] | 0.31 | |
| G | 69.3 (338/488) | 76.6 (291/380) | Reference | - | |
| A | 30.7 (150/488) | 23.4 (89/380) | 1.46 [1.04–2.05] | 0.03 | |
| A non-carriers | 47.5 (116/244) | 61.1 (116/190) | Reference | - | |
| A carriers | 52.5 (128/244) | 38.9 (74/190) | 1.74 [1.14–2.65] | 0.01 | |
| rs2010963 | GG | 44.7 (109/244) | 40.8 (78/191) | Reference | - |
| GC | 42.2 (103/244) | 44.5 (85/191) | 0.80 [0.51–1.25] | 0.32 | |
| CC | 13.1 (32/244) | 14.7 (28/191) | 0.66 [0.34–1.25] | 0.20 | |
| G | 65.8 (321/488) | 63.1 (241/382) | Reference | - | |
| C | 34.2 (167/488) | 36.9 (141/382) | 0.80 [0.59–1.08] | 0.15 | |
| C non-carriers | 44.7 (109/244) | 40.8 (78/191) | Reference | - | |
| C carriers | 55.3 (135/244) | 59.2 (113/191) | 0.76 [0.50–1.16] | 0.20 | |
| rs3025020 | CC | 50.4 (123/244) | 53.7 (102/190) | Reference | - |
| CT | 39.8 (97/244) | 39.5 (75/190) | 1.13 [0.73–1.76] | 0.57 | |
| TT | 9.8 (24/244) | 6.8 (13/190) | 1.57 [0.69–3.54] | 0.28 | |
| C | 70.3 (343/488) | 73.4 (279/380) | Reference | - | |
| T | 29.7 (145/488) | 26.6 (101/380) | 1.20 [0.86–1.67] | 0.28 | |
| T non-carriers | 50.4 (123/244) | 53.7 (102/190) | Reference | - | |
| T carriers | 49.6 (121/244) | 46.3 (88/190) | 1.20 [0.79–1.82] | 0.40 | |
| rs3025039 | CC | 77.5 (189/244) | 70.8 (136/192) | Reference | - |
| CT | 20.5 (50/244) | 25.5 (49/192) | 0.63 [0.38–1.04] | 0.07 | |
| TT | 2.0 (5/244) | 3.7 (7/192) | 1.09 [0.24–5.02] | 0.91 | |
| C | 87.7 (428/488) | 83.6 (321/384) | Reference | - | |
| T | 12.3 (60/488) | 16.4 (63/384) | 0.72 [0.47–1.12] | 0.14 | |
| T non-carriers | 77.5 (189/244) | 70.8 (136/192) | Reference | - | |
| T carriers | 22.5 (55/244) | 29.2 (56/192) | 0.66 [0.41–1.06] | 0.09 |
* OR (95% CI) and p-values were adjusted by sex, age, smoking history, and packs of cigarettes per year. CI: confidence interval; IIP: Idiopathic interstitial pneumonia; N: Total number of individuals successfully genotyped; OR: Odds ratio; VEGF: Vascular endothelial growth factor.