Table 4.
Haplotype differences of VEGF between the whole group of patients with ILD and healthy controls, and between IIP and non-IIP patients.
| Whole Cohort of ILD Patients versus Controls | IIP versus Non-IIP Patients | |||||||
|---|---|---|---|---|---|---|---|---|
| Haplotype * | Frequency in ILD % (n/N) |
Frequency in Controls % (n/N) |
OR [95% CI] | p-Value | Frequency in IIP % (n/N) |
Frequency in Non-IIP % (n/N) |
OR [95% CI] ‡ | p-Value ‡ |
| TGGCC | 31.4 (271/862) | 32.6 (330/1012) | Reference | - | 30.7 (150/488) | 32.4 (121/374) | Reference | - |
| TGCCC | 10.7 (92/862) | 9.8 (99/1012) | 1.13 [0.82–1.57] | 0.46 | 10.0 (49/488) | 11.5 (43/374) | 0.81 [0.48–1.36] | 0.42 |
| CAGCC | 7.1 (61/862) | 9.3 (94/1012) | 0.79 [0.55–1.13] | 0.20 | 7.8 (38/488) | 6.2 (23/374) | 1.11 [0.60–2.05] | 0.74 |
| CGGCC | 7.5 (65/862) | 7.7 (78/1012) | 1.01 [0.70–1.46] | 0.94 | 8.6 (42/488) | 6.2 (23/374) | 1.56 [0.86–2.86] | 0.15 |
| CAGTC | 8.1 (70/862) | 7.6 (77/1012) | 1.11 [0.77–1.59] | 0.58 | 9.4 (46/488) | 6.4 (24/374) | 1.67 [0.92–3.05] | 0.09 |
* The polymorphism order was rs833081, rs1570360, rs2010963, rs3025020, and rs3025039. ‡ OR 95% CI and p-values were adjusted by sex, age, smoking history, and packs of cigarettes per year. CI: Confidence interval; IIP: Idiopathic interstitial pneumonia; ILD: Interstitial lung disease; N: Total number of individuals successfully genotyped; OR: Odds ratio; VEGF: Vascular endothelial growth factor.