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. 2021 Apr 26;9(5):471. doi: 10.3390/biomedicines9050471

Figure 3.

Figure 3

Top 7 KEGG biological pathways revealed by analyzing target miRNAs between NLF-EVs of CRS patients and HCs using DIANA tools. (A) Overexpressed miRNAs in NLF-EVs of CRS patients compared to HCs after adjustment of the outlier values according to the Chauvenet criterion (Student’s t-test; * p < 0.05; ** p < 0.01, ns > 0.05). (B) KEGG enrichment analysis of all DEGs with |FC| > 2 (cutoff). (C) Pathway enriched by up- and downregulated genes and sorted by the value of −log10(p-value). (D) Diagram of the mucin-type O-glycan biosynthesis. Five dysregulated miRNAs (miR-223-3p, miR-23a-3p, miR-15a-5p, miR-1285-3p, and miR-450a-1-3p) were associated with the mucin-type O-glycan biosynthesis by possibly regulating their potential gene targets. KEGG, Kyoto Encyclopedia Gene and Genome; miRNA, microRNA; NLF, nasal lavage fluid; EV, extracellular vesicle; CRS, chronic rhinosinusitis; HC, healthy control; DEG, differentially expressed gene; FC, fold change.