Table 1.
Summary characteristics of studies reporting on genetic predictors of SOS (n = 27).
| Characteristics | n | Proportion (%) |
|---|---|---|
| Centers included | ||
| monocentric | 20 | 74.1 |
| multicentric | 6 | 22.2 |
| unclear | 1 | 3.7 |
| Location | ||
| Europe | 11 | 40.7 |
| North America | 9 | 33.3 |
| Asia | 4 | 14.8 |
| Others | 3 | 11.1 |
| Study design | ||
| cohort | 23 | 85.2 |
| prospective trial | 2 | 7.4 |
| case-control | 2 | 7.4 |
| Sample size | ||
| median, IQR (n) | 84 | 65–142 |
| 0–50 | 3 | 11.1 |
| 51–100 | 13 | 48.1 |
| 101–150 | 4 | 14.8 |
| 151–200 | 4 | 14.8 |
| 201 and more | 3 | 11.1 |
| Age group at treatment | ||
| children and adolescents only | 10 | 37 |
| children, adolescents, and adults | 11 | 40.7 |
| adults only | 6 | 22.2 |
| Treatment exposure | ||
| allogeneic HSCT, busulfan-based | 10 | 37 |
| allogeneic HSCT, various regimens | 9 | 33.3 |
| autologous and allogeneic HSCT | 4 | 14.8 |
| non-HSCT | 4 | 14.8 |
| Outcome | ||
| incidence cohort-based samples (mean %, range %) | 16.5 | 2.3–42.9 |
| (modified) Seattle criteria | 15 | 55.6 |
| Baltimore criteria | 5 | 18.5 |
| other criteria/unspecified | 7 | 25.9 |
| Association analysis | ||
| candidate gene analysis | 26 | 96.3 |
| genome/exome wide analysis | 1 | 3.7 |
Legend: HSCT, hematopoietic stem cell transplantation; IQR, interquartile range; n, number.