Table 3. The enriched GO terms of the up- and down-regulated DEGs.
| GO ID | CATEGORY | GO Name | P Value | FDR B and H | FDR B and Y | Bonferroni | Gene count | Gene |
|---|---|---|---|---|---|---|---|---|
| Up-regulated genes | ||||||||
| GO:0000003 | BP | reproduction | 1.54E-05 | 1.92E-02 | 1.75E-01 | 7.69E-02 | 59 | CEBPB, GRHL2, ACSL4, S100A11, KMT2C, UBE2A, TESK2, AGFG1, AHR, HES1, MAFF, HSD11B2, PAQR7, RHOBTB3, NECTIN3, CRH, SLC4A2, STS, CSNK2A2, SLC22A5, GABRB1, PLAC1, SPIRE2, PSG1, PSG2, ING2, PSG3, INHA, PSG4, PSG5, PSG6, PSG7, PSG9, CYP11A1, PSG11, CYP19A1, YTHDC1, SEPTIN6, STAT5B, CREBRF, NFE2, SPIN1, STRA6, MBD2, DDR1, TBX3, CAST, CGB7, TEAD3, LHB, GMCL1, OVGP1, TIAL1, EGFR, INSL6, LNPEP, TLR3, TMF1, PLEKHA1 |
| GO:0009057 | BP | macromolecule catabolic process | 5.89E-04 | 1.28E-01 | 1.00E+00 | 1.00E+00 | 48 | CARHSP1, RPS13, WAC, UBE2A, UBE2D3, CLN3, UCHL3, LYPLA1, HSPB1, HSP90AA1, AMFR, DCP2, IDS, AZIN1, IGF2BP3, IGF2BP2, GET4, CSNK2A2, MTM1, NCAN, TNKS1BP1, USP33, TRIM25, PSMA3, PSMC4, DDB1, CREBRF, PTPN3, STX5, FBXO9, SMG9, PJA1, USP27X, RBX1, RBBP6, CAST, RDX, PELI1, NCCRP1, STT3B, RYBP, OVGP1, EGFR, TIMP2, LNPEP, PKP3, FURIN, TMF1 |
| GO:0042175 | CC | nuclear outer membrane- endoplasmic reticulum membrane network | 1.06E-03 | 1.69E-01 | 1.00E+00 | 6.75E-01 | 38 | SPTLC3, CDS1, BET1, ACSL4, SPCS3, PIGH, EVA1A, CLN3, HSD3B1, ULK1, HSD11B2, FKBP2, AMFR, FOLR1, SPTLC1, RAB3GAP1, STS, NSG1, GDPD1, GPAA1, CYP19A1, STX5, BCAP29, NUP153, TOR1AIP2, CAMK2G, NUCB2, CASP4, TMED4, STT3B, RASGRP1, MFSD2A, SPPL2A, EGFR, LPCAT3, FURIN, TLR3, PAFAH2 |
| GO:0005794 | CC | Golgi apparatus | 1.36E-02 | 3.09E-01 | 1.00E+00 | 1.00E+00 | 46 | SGSM1, CNST, BET1, SPG21, ST3GAL6, CLN3, AMFR, ANK3, FOLR1, GDF15, YIPF4, RHOBTB3, ST3GAL4, RAB3GAP1, STS, NCAN, NSG1, PDE4DIP, RAB11FIP5, FHDC1, TBC1D23, STX11, CSGALNACT1, ECE2, USP33, ACER2, ATP6V0C, ING2, STK26, C1GALT1, COG3, BMP1, STX5, AP1G2, TAF7, GOLGA4, YIPF6, NUCB2, TMED4, LHB, RASGRP1, EGFR, FURIN, TLR3, TMF1, ELF3 |
| GO:0042802 | MF | identical protein binding | 4.89E-03 | 2.96E-01 | 1.00E+00 | 1.00E+00 | 59 | CEBPB, IER5, TWIST1, S100A11, S100P, H2BC8, H2BC6, H2BC4, TLE5, CLK3, AHR, UCK2, TRPV6, HES1, HOOK2, ULK1, HSPB1, CAP2, HSP90AA1, AMFR, GDF15, ANXA4, SRR, CLDN7, NECTIN3, CGGBP1, TBK1, GRAMD2B, ATF3, RIPOR2, STK26, NAB2, DAPK1, BMP1, JUP, DHPS, SMG9, KYNU, HSPB8, NUP153, YIPF6, CAMK2G, DYRK1A, GRB7, RDX, UBA3, TDG, CLDN8, TFRC, GMCL1, RASGRP1, SPPL2A, EGFR, CBX5, ENTPD1, TLR3, PAK1, PAK2, SPATA13 |
| GO:0098772 | MF | molecular function regulator | 1.03E-02 | 2.96E-01 | 1.00E+00 | 1.00E+00 | 55 | SGSM1, NET1, PDPK1, DENND2D, SERPINI1, AGFG1, TNFAIP8, HSPB1, RASAL2, HSP90AA1, DNAJB1, FNTA, GDF15, ANXA4, CRH, AZIN1, RAB3GAP1, CSH2, PPP4R2, ATP1B3, DEPDC1B, RIPOR2, INHA, MYO9A, INSL4, GH2, BMP1, PTPN3, CGB1, SEMA3B, RGL2, TOR1AIP2, RGPD8, PPP1R14C, TFPI2, FBRS, CAST, CGB7, COX17, PPP1R14B, ITIH5, LHB, RASGRP1, EEF1B2, GRTP1, FAM13A, EGFR, INSL6, TIMP2, FURIN, TLR3, PAK2, MARK2, ENSA, SPATA13 |
| Down-regulated genes | ||||||||
| GO:0007155 | BP | cell adhesion | 4.46E-28 | 8.58E-25 | 7.92E-24 | 2.57E-24 | 104 | CLDN14, ABL1, ENPP2, VSIG4, EMILIN2, LAMC3, PGM5, NRARP, FZD4, SLIT2, MFAP4, MFGE8, FAT1, FBLN2, MYL9, CD99, SPON1, JAG1, GPC4, ANTXR1, SRPX, VCAM1, VCL, FOXF1, COL1A1, PMP22, VEGFC, COL3A1, COL5A1, COL6A1, COL6A2, FLNA, COL6A3, COL8A2, FBLN5, VTN, VWF, COL16A1, ABI3BP, PODXL, FOLR2, EGFL6, CYFIP2, LIMS2, PDPN, RND3, IGFBP2, CCM2L, IGFBP7, FEZ1, PPM1F, VCAN, PARVA, SNAI2, AOC3, PRKCA, CCN2, EGFLAM, EPDR1, FYN, NEXN, MYADM, MYO10, AXL, ADAM15, PIEZO1, TNFRSF14, GAS6, ITGA1, TNFRSF21, LYVE1, PTPRD, ADAMTS9, ACKR3, WNT3A, NECTIN2, FERMT2, RARA, SH2B3, DDR2, LAMA2, LAMA4, LAMB2, LAMC1, CAV1, TEK, DLL1, PIP5K1C, LGALS1, TGFB1I1, TGFBI, HAVCR2, COL18A1, THY1, FAM107A, CD36, LPP, CD44, CD81, CLDN5, CDH6, CDH11, SMAD3, EPHA3 |
| GO:0051674 | BP | localization of cell | 2.02E-23 | 1.67E-20 | 1.54E-19 | 1.17E-19 | 111 | ABL1, ABR, MAP1B, APCDD1, PDGFRB, ENPP2, MATN2, ACTA2, CYGB, TMIGD3, SOX18, LAMC3, F3, ADCY3, SEMA3A, SLIT2, FAT1, MGAT3, EFEMP1, CD99, JAG1, AGTR1, GPC4, CCL13, CMKLR1, CNN2, VCAM1, VCL, FOXF1, COL1A1, COL1A2, PMP22, VEGFC, COL3A1, COL5A1, FLNA, DDIT4, VTN, ADAMTS1, PODXL, FOLR2, CXCL14, ADGRA2, PDPN, RND3, ARHGAP4, IGFBP3, PRCP, PPM1F, VCAN, CSPG4, SLIT3, PARVA, SNAI2, AOC3, PRKCA, PKN1, CCN2, EGFLAM, CAVIN1, FSCN1, FYN, NEXN, HYAL2, PROS1, MYADM, SPARC, MYO10, AXL, ADAM15, TNFRSF14, GAS6, TUBB2B, NDN, ITGA1, DCN, STAT3, STC1, ADAMTS9, BST2, ACKR3, TSPO, RIPOR1, BRAT1, RAP2A, RARRES2, CD248, GPER1, DDR2, LAMA2, LAMA4, LAMB2, LAMC1, CAV1, TEK, PIP5K1C, LPAR1, LDB2, COL18A1, ARAP3, THY1, LMNA, FAM107A, TIMP1, ATOH8, CD44, SPRED1, CD81, ARHGEF2, SMAD3, EPHA3 |
| GO:0099080 | CC | supramolecular complex | 3.08E-13 | 1.81E-11 | 1.24E-10 | 1.63E-10 | 77 | TPM2, CYBRD1, MAP1B, ACTA2, ACTG2, TUBB2A, PGM5, TBCB, MFAP4, PARP4, FAT1, MYL9, PEMT, ANTXR1, CCDC151, CNN2, VCAM1, VCL, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL6A1, FLNA, COL6A3, BIN1, SHROOM3, FBLN5, SEPTIN4, PODXL, NCKAP5L, ADGRA2, SMTN, PDPN, ARHGAP4, FEZ1, PARVA, AOC3, FSCN1, FYN, NEXN, HYAL2, NES, MYH11, NEK6, MYO10, SEPTIN9, SPTAN1, TUBB2B, AIF1L, DCN, PTH1R, ITPR3, PDLIM3, SVIL, FERMT2, DPYSL2, CALD1, GPER1, SYNM, TEK, RHOQ, ABLIM1, OXTR, LMNA, FAM107A, FARP1, CD36, LPP, CD44, PALM, ARHGEF2, TNNT3 |
| GO:0030054 | CC | cell junction | 3.95E-13 | 2.09E-11 | 1.43E-10 | 2.09E-10 | 71 | CLDN14, MAP1B, PDGFRB, PGM5, FZD4, FAT1, CAMK2N1, CD99, JAG1, FGFR3, CNN2, ARHGEF6, VCL, PMP22, FLNA, SHROOM3, PODXL, YWHAH, CYFIP2, LIMS2, PDPN, RND3, CSPG4, PARVA, PRKCA, EGFLAM, FSCN1, NEXN, RAB23, MYADM, LYPD6, ADAM15, SPTAN1, B2M, CCND1, AIF1L, ITGA1, RASIP1, GJA4, PDLIM3, SYT11, ARHGAP44, SVIL, NECTIN2, YWHAQ, FERMT2, GPER1, SYNM, DDR2, LASP1, CAV1, CAV2, TEK, DLL1, PIP5K1C, TGFB1I1, HAVCR2, OXTR, THY1, FAM107A, FARP1, LPP, CD44, TSPAN4, CD81, CLDN5, CGNL1, ARHGEF2, AGRN, CDH6, CDH11 |
| GO:0005102 | MF | signaling receptor binding | 6.59E-08 | 6.11E-06 | 4.59E-05 | 6.72E-05 | 75 | CMTM3, ABL1, CRLF1, PDGFRB, ETS2, SEMA3A, SLIT2, MFGE8, EFEMP1, JAG1, AGTR1, CCL13, LTBP4, VCAM1, VEGFC, COL3A1, COL5A1, FLNA, FBLN5, VTN, VWF, COL16A1, CNRIP1, CXCL14, ALKAL2, YWHAH, EGFL6, PDPN, IGFBP2, IGFBP4, SLIT3, NCOA1, PRKCA, PKN1, CCN2, FYN, DKK3, HYAL2, NES, ADAM15, B2M, GAS6, ITGA1, STAT3, STC1, PXDN, PTPRD, WNT3A, PLSCR4, RARA, RARRES2, SH2B3, SH2D3C, LAMA2, LAMA4, LAMB2, CAV1, CAV2, DLL1, TGFB1I1, TGFB3, LEFTY2, TGFBI, RSPO3, ANGPTL2, THY1, TIMP1, CD36, CD44, TSPAN4, PALM, SPRED1, CD81, CMTM7, SMAD3 |
| GO:0098772 | MF | molecular function regulator | 2.41E-05 | 1.12E-03 | 8.38E-03 | 2.46E-02 | 69 | CMTM3, CRLF1, ABR, CTSC, PPP1R14A, SEMA3A, SLIT2, CAMK2N1, EFEMP1, JAG1, CCL13, SIPA1L2, DOCK6, SMAP2, ARHGEF6, VEGFC, FLNA, COL6A3, WARS1, CXCL14, ALKAL2, YWHAH, PPP1R3C, TXNIP, ARHGAP4, PPP2R2B, IGFBP3, LAMTOR4, CCN2, GPSM1, DKK3, HYAL2, CYTH4, PROS1, LYPD6, RAPGEF5, GAS6, CCND1, INKA2, STC1, RGL1, AFAP1L2, PXDN, BST2, WNT3A, ARHGAP44, RIPOR1, FGD5, RAB3IL1, RARA, SH2D3C, WFDC1, RENBP, CAV1, RGS10, CCND2, CCND3, TGFB3, LEFTY2, ARAP3, THY1, TIMP1, ABCE1, FARP1, SPRED1, ARHGEF2, CMTM7, AGRN, PCOLCE |
BP, CC and MF.