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. 2021 May 21;41(5):BSR20210617. doi: 10.1042/BSR20210617

Table 4. The enriched pathway terms of the up- and down-regulated DEGs.

Pathway ID Pathway Name P-value FDR B& H FDR B&Y Bonferroni Gene Count Gene
Up-regulated genes
1269373 Cell surface interactions at the vascular wall 2.86E-05 4.73E-03 3.47E-02 2.46E-02 13 PSG8, SLC3A2, ATP1B3, PSG1, PSG2, PSG3, PSG4, PSG5, PSG6, PSG7, PSG9, PSG11, GRB7
1269734 Epigenetic regulation of gene expression 8.47E-04 2.18E-02 1.60E-01 7.28E-01 11 H2AC6, H2BC8, H2BC6, H2BC4, H2BC21, H4C8, H2BC12, MBD2, TAF1B, TDG, H2BC5
1270001 Metabolism of lipids and lipoproteins 1.33E-03 2.87E-02 2.10E-01 1.00E+00 33 OLAH, SPTLC3, CDS1, ACADVL, ACOX3, ACSL4, AHR, PIP5K1B, HSD3B1, TNFAIP8, HSD11B2, SH3KBP1, SPTLC1, TNFAIP8L1, PLEKHA6, STS, CSNK2A2, MTM1, ACER2, GDPD1, CYP11A1, CYP19A1, BMP1, TEAD3, LHB, MFSD2A, MTMR4, ABHD5, LPCAT3, FURIN, AKR1B15, PLEKHA1, RORA
1268701 Post-translational protein modification 3.57E-03 6.02E-02 4.41E-01 1.00E+00 38 BET1, WAC, H2AC6, H2BC8, UBE2A, H2BC6, H2BC4, UBE2D3, H2BC21, ST3GAL6, PIGH, UCHL3, ADAMTSL4, H2BC12, AMFR, ANK3, FOLR1, ST3GAL4, STS, BABAM1, USP33, TRIM25, GPAA1, INO80C, PSMA3, PSMC4, C1GALT1, COG3, H2AW, STX5, DHPS, NUP153, RAB25, GNE, TDG, LHB, FURIN, H2BC5
1268677 Metabolism of proteins 1.06E-02 1.30E-01 9.49E-01 1.00E+00 52 ACADVL, BET1, RPS13, WAC, H2AC6, SPCS3, H2BC8, UBE2A, H2BC6, H2BC4, UBE2D3, H2BC21, ST3GAL6, PIGH, H4C8, UCHL3, ADAMTSL4, H2BC12, AMFR, ANK3, FOLR1, DCP2, ST3GAL4, STS, BABAM1, CSNK2A2, ATF3, ATF4, CGB5, USP33, CHCHD10, TRIM25, GPAA1, INO80C, INHA, PSMA3, PSMC4, C1GALT1, COG3, H2AW, STX5, GNG12, DHPS, NUP153, RAB25, GNE, COX17, TDG, LHB, EEF1B2, FURIN, H2BC5
1270302 Developmental Biology 1.79E-02 1.92E-01 1.00E+00 1.00E+00 36 CEBPB, RPS6KA5, PFN2, KMT2C, H2AC6, H2BC8, H2BC6, H2BC4, H2BC21, H4C8, HES1, H2BC12, RASAL2, CAP2, HSP90AA1, ANK3, KRT23, CSNK2A2, NCAN, PSMA3, PSMC4, JUP, KAZN, KRTAP26-1, RBX1, CAMK2G, GRB7, RDX, RASGRP1, TCHH, EGFR, PKP3, FURIN, PAK1, PAK2, H2BC5
Down-regulated genes
1270244 Extracellular matrix organization 1.93E-23 1.40E-20 1.00E-19 1.40E-20 46 LAMC3, MFAP4, FBLN2, EFEMP1, PLOD1, LTBP4, VCAM1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, COL8A2, FBLN5, VTN, FMOD, COL16A1, ADAMTS1, EFEMP2, VCAN, PRKCA, SPARC, ADAM15, ITGA1, DCN, ADAMTS9, P4HA2, DDR2, LAMA2, LAMA4, LAMB2, LAMC1, COLGALT1, TGFB3, COL18A1, TIMP1, CD44, LTBP2, AGRN, PCOLCE
1270303 Axon guidance 3.15E-05 1.35E-03 9.67E-03 2.29E-02 31 ABL1, PDGFRB, RPS6KA2, SEMA3A, SLIT2, MYL9, FGFR3, VCL, COL4A1, COL4A2, COL4A5, COL6A1, COL6A2, COL6A3, VWF, SLIT3, PRKCA, FYN, MYH11, MYO10, SPTAN1, ITGA1, GFRA2, DPYSL2, LAMC1, TEK, PIP5K1C, ABLIM1, SPRED1, AGRN, EPHA3
1269478 Signaling by PDGF 2.76E-04 7.15E-03 5.13E-02 2.00E-01 22 PDGFRB, ADCY3, FGFR3, VCL, COL4A1, COL4A2, FOXO1, COL4A5, COL6A1, COL6A2, COL6A3, ADCY4, VWF, PRKCA, FYN, SPTAN1, GFRA2, STAT3, ITPR3, TEK, PIP5K1C, SPRED1
1269340 Hemostasis 1.83E-03 3.51E-02 2.51E-01 1.00E+00 29 ABL1, PDE9A, F3, EHD2, CD99, DOCK6, VCL, VEGFC, FLNA, VWF, PDPN, PRCP, PRKCA, FYN, PROS1, SPARC, GAS6, ITGA1, ITPR3, CFD, RARRES2, SH2B3, CAV1, TEK, TGFB3, LEFTY2, TIMP1, CD36, CD44
1270302 Developmental Biology 6.14E-03 8.76E-02 6.28E-01 1.00E+00 41 ABL1, PDGFRB, RPS6KA2, SEMA3A, SLIT2, MYL9, FGFR3, VCL, COL4A1, COL4A2, FOXO1, COL4A5, COL6A1, COL6A2, COL6A3, VWF, SLIT3, NCOA1, PRKCA, FYN, MYH11, MYO10, SPTAN1, ITGA1, GFRA2, STAT3, TCF4, DPYSL2, RARA, LAMC1, EBF1, TEK, PIP5K1C, CCND3, LEFTY2, ABLIM1, CD36, SPRED1, AGRN, SMAD3, EPHA3
1269310 Cytokine Signaling in Immune system 6.57E-03 9.18E-02 6.58E-01 1.00E+00 31 CRLF1, UBE2L6, PDGFRB, IFITM3, FGFR3, VCAM1, VCL, COL1A2, FOXO1, VWF, IFITM2, IFNGR2, FSCN1, FYN, SPTAN1, B2M, TNFRSF14, CCND1, NDN, GFRA2, STAT3, BST2, TRIM8, TEK, HAVCR2, TIMP1, CD36, CD44, SPRED1, IRAK3, TNFRSF1B