Table 5. Topology table for up- and down-regulated genes.

Regulation	Node	Degree	Betweenness	Stress	Closeness
Up	HSP90AA1	655	0.22721	81351654	0.412863
Up	EGFR	324	0.081831	21358048	0.396682
Up	RPS13	176	0.040553	21024400	0.332742
Up	RBX1	132	0.02978	9542636	0.3408
Up	PAK1	115	0.016755	4561194	0.37158
Up	CSNK2A2	112	0.026157	6172590	0.354758
Up	PAK2	107	0.012051	4334042	0.349858
Up	DDB1	105	0.024917	6240978	0.340602
Up	PSMC4	101	0.019368	3810802	0.348739
Up	DVL3	99	0.017256	5360158	0.344762
Up	UBE2D3	96	0.018158	6872298	0.333975
Up	SMARCB1	90	0.021042	7085456	0.333215
Up	STAT5B	89	0.005633	1782886	0.349937
Up	STX5	86	0.021729	5783250	0.327692
Up	UBE2A	86	0.01665	6800442	0.330652
Up	NUP153	81	0.019493	3839268	0.33388
Up	JUP	79	0.012614	3875882	0.320148
Up	PSMA3	78	0.009276	2735940	0.330535
Up	SH3KBP1	76	0.011315	2648130	0.345321
Up	HSPB1	69	0.012593	3676246	0.34167
Up	BET1	67	0.013941	4543480	0.325711
Up	AMFR	66	0.018899	2411936	0.345907
Up	RRAS2	64	0.00438	2166928	0.301914
Up	MARK2	63	0.012107	3287228	0.338315
Up	CBX5	62	0.015481	3171408	0.327807
Up	CEBPB	62	0.007601	2245984	0.350172
Up	PDPK1	62	0.005919	1612918	0.342169
Up	HNRNPH1	59	0.013608	2423406	0.335625
Up	DNAJB1	58	0.00611	1362926	0.344205
Up	ATF3	57	0.005226	1555506	0.352755
Up	SPATA13	56	0.00717	2217896	0.295759
Up	FURIN	55	0.017306	2333572	0.332317
Up	RHOBTB1	54	0.005265	891404	0.309798
Up	SNAP23	52	0.010301	2133980	0.326551
Up	STX11	49	0.006356	1012388	0.276999
Up	TBK1	48	0.00946	1612462	0.346521
Up	RAB25	48	0.00796	4209932	0.282579
Up	ING2	42	0.006848	2338492	0.325236
Up	ULK1	42	0.007643	7120856	0.274292
Up	UCHL3	42	0.007629	1994146	0.325779
Up	PFN2	41	0.004889	1200798	0.329235
Up	CAP2	40	0.002011	661156	0.288156
Up	UBA3	40	0.005749	1625200	0.326187
Up	DYRK1A	40	0.004394	1121650	0.309634
Up	RBM22	39	0.01146	1346380	0.322616
Up	TXK	38	0.001513	482866	0.300558
Up	TAF7	38	0.010147	1476134	0.322972
Up	CAMK2G	38	0.007152	1050770	0.341969
Up	ATF4	37	0.006742	1255258	0.328036
Up	TLR3	36	0.004686	1054636	0.305217
Up	MYO9A	36	8.05E-04	406980	0.28752
Up	BABAM1	36	0.008431	1423346	0.324044
Up	STK26	36	0.008804	1319200	0.323842
Up	ACTR3C	35	0.002617	659206	0.282732
Up	CREB5	35	0.001154	566084	0.298035
Up	NET1	33	0.003076	787876	0.327189
Up	EEF1B2	32	0.00465	1484558	0.32501
Up	AHR	32	0.003156	847220	0.347858
Up	PIP5K1B	31	0.00183	957308	0.326391
Up	CLN3	31	0.007159	992822	0.323485
Up	HES1	30	0.0035	796872	0.300115
Up	RBBP6	29	0.008094	1087968	0.324089
Up	AP1G2	29	0.008892	933344	0.321377
Up	RDX	29	0.003378	953914	0.325146
Up	RGPD8	28	0.002967	626564	0.32295
Up	HSD3B1	28	0.009418	6545696	0.230497
Up	COG3	27	0.00261	458374	0.24988
Up	ATP6V0C	27	0.008472	953284	0.320959
Up	TFRC	27	0.004398	847110	0.329004
Up	TIAL1	27	0.005954	1083682	0.323485
Up	DCP2	27	0.007451	4215608	0.243872
Up	CAPZA1	26	0.002869	626878	0.325191
Up	FKBP2	25	0.003414	683462	0.282255
Up	TWIST1	24	0.001372	488874	0.298643
Up	TIMP2	24	0.001662	741652	0.250924
Up	SPTLC1	24	0.008272	878220	0.320827
Up	DAPK1	24	0.003354	582304	0.3437
Up	STT3B	23	0.005888	688678	0.320805
Up	RBMS1	23	0.005223	803708	0.322772
Up	ANK3	21	0.004965	565126	0.321819
Up	TDG	21	0.00124	515588	0.326346
Up	CHMP5	20	0.00503	681262	0.320915
Up	MBD2	20	0.003168	3223460	0.265195
Up	TRIM25	20	0.002013	463938	0.326073
Up	TEAD3	20	0.001225	501618	0.323954
Up	SLC3A2	20	0.005187	569152	0.332435
Up	BMP1	19	0.00311	565522	0.259095
Up	RHOBTB3	19	0.002152	346198	0.322439
Up	CHD2	19	0.00121	998828	0.256894
Up	RYBP	19	0.002415	541940	0.322572
Up	GLRX	18	0.00459	583470	0.320959
Up	KMT2C	18	0.003676	553422	0.285019
Up	YTHDC1	18	0.003349	530960	0.33407
Up	GRB7	18	5.17E-04	151894	0.294958
Up	IWS1	17	0.004258	1715034	0.236798
Up	TRAF3IP2	17	0.001901	398464	0.324246
Up	CSF3R	17	0.001832	324530	0.329027
Up	AFF1	17	0.003482	1512904	0.247805
Up	INO80C	17	0.003498	441732	0.321245
Up	CASP4	17	0.002253	931980	0.263822
Up	YIPF6	17	0.003441	5013996	0.201367
Up	PCGF1	16	0.003259	409788	0.320827
Up	CXCR2	16	0.003899	2017434	0.253558
Up	ELF3	16	6.72E-04	203260	0.333452
Up	USP33	16	0.002932	430028	0.322927
Up	AGFG1	15	0.003227	435804	0.321443
Up	LNPEP	14	7.10E-04	211470	0.322483
Up	RORA	14	0.001493	299584	0.282187
Up	LARP1B	14	0.004683	546700	0.321708
Up	ACSL4	14	0.005208	423594	0.320388
Up	ESRRG	14	0.001317	573474	0.244687
Up	MXD1	13	6.21E-04	548286	0.273427
Up	GET4	13	0.001988	297146	0.321113
Up	NFE2	13	0.001758	361494	0.277475
Up	SCNN1B	13	0.001794	293352	0.321863
Up	TBX3	11	0.00107	660104	0.254826
Up	TAF1B	11	0.00167	339720	0.323106
Up	ADK	11	0.003862	318638	0.320257
Up	CLK3	11	0.001752	276054	0.272997
Up	PELI1	10	0.001025	246998	0.322195
Up	PHYHIPL	2	1.23E-05	3410	0.238801
Up	MAFF	2	8.27E-06	5370	0.260986
Up	TESK2	2	1.97E-05	2606	0.259425
Up	MTMR4	1	0	0	0.259138
Up	ZFAND6	1	0	0	0.230519
Up	ACP1	1	0	0	0.27858
Up	EFS	1	0	0	0.27858
Up	RAB11FIP5	1	0	0	0.220331
Up	CYP11A1	1	0	0	0.187328
Up	ADAM12	1	0	0	0.230951
Up	FBXO9	1	0	0	0.25419
Up	HSPB8	1	0	0	0.254674
Up	CCNDBP1	1	0	0	0.256234
Up	LTBP3	1	0	0	0.217731
Up	FNTA	1	0	0	0.246424
Up	ACOX3	1	0	0	0.24266
Up	PJA1	1	0	0	0.24372
Up	SERTAD4	1	0	0	0.247308
Up	EID2	1	0	0	0.259138
Up	AKTIP	1	0	0	0.254951
Up	SPTLC3	1	0	0	0.242911
Up	SGSM1	1	0	0	0.246424
Up	LRRC69	1	0	0	0.292236
Down	FYN	305	0.060673	15146282	0.386124
Down	ABL1	256	0.044808	14298188	0.385806
Down	SMAD3	209	0.042609	22810928	0.349754
Down	STAT3	202	0.037341	10226766	0.378422
Down	PRKCA	182	0.041662	11865040	0.377234
Down	ACTA2	161	0.02569	7462512	0.366351
Down	YWHAH	149	0.028069	10474112	0.350015
Down	ACTG2	131	0.011051	3779892	0.354141
Down	RPL14	127	0.022838	13966136	0.331377
Down	PDGFRB	123	0.013902	4225738	0.358778
Down	CCND1	119	0.017659	8841110	0.344483
Down	PPM1F	119	0.016265	6535610	0.32041
Down	CAV1	113	0.018938	4593828	0.368628
Down	YWHAQ	101	0.013637	4845932	0.355674
Down	FOXO1	96	0.015104	5652522	0.349128
Down	WNT3A	95	0.013629	4052094	0.299674
Down	RHOQ	92	0.016733	3678142	0.331471
Down	TUBB2A	91	0.012587	3886552	0.334213
Down	FGFR3	83	0.010949	3642512	0.326755
Down	RARA	81	0.013223	4465300	0.341869
Down	MYH11	72	0.01194	3062450	0.35249
Down	HIPK2	72	0.01135	3565432	0.339639
Down	HSPA12B	68	0.003037	744544	0.301991
Down	RPS6KA2	68	0.005549	2522498	0.317738
Down	TEK	66	0.004665	1653094	0.338168
Down	NCOA1	65	0.008395	3153458	0.31475
Down	VCL	63	0.009681	2780132	0.338217
Down	TUBB2B	62	0.00676	1694194	0.343977
Down	PPP2R2B	62	0.010479	4191976	0.328542
Down	TPM2	62	0.006776	1763750	0.334428
Down	SPTAN1	62	0.011399	2596256	0.334046
Down	MYL9	60	0.008098	2479906	0.335361
Down	DIMT1	58	0.008481	2242228	0.327326
Down	TCF4	54	0.009445	2760706	0.330629
Down	MRPL34	52	0.006656	17810170	0.236106
Down	CCND3	51	0.003239	1601134	0.295927
Down	LMNA	47	0.00911	2401846	0.338682
Down	PKN1	46	0.003592	1349794	0.299559
Down	CD44	46	0.010187	2270300	0.349493
Down	DCN	45	0.007594	1930616	0.322283
Down	ADCY3	45	0.008618	1694556	0.33133
Down	TGFB1I1	45	0.003137	931752	0.325349
Down	EPHA3	44	0.002379	661600	0.318884
Down	FZD4	43	0.005096	1738748	0.327006
Down	RND3	42	0.006152	1123788	0.333832
Down	ADCY4	41	0.001819	672196	0.287785
Down	ETS2	41	0.004246	1834106	0.329559
Down	RAP2A	40	0.007351	1433240	0.326983
Down	CCND2	40	0.002601	1155154	0.334046
Down	AXIN2	39	0.00394	1203884	0.333618
Down	OPTN	37	0.00695	1707428	0.328289
Down	UBE2L6	37	0.005601	1462120	0.327189
Down	PIP5K1C	37	0.002815	1263578	0.334714
Down	MAP1B	34	0.007029	1488054	0.325371
Down	AXL	34	0.002374	729250	0.345881
Down	IRAK3	33	8.12E-04	865022	0.277229
Down	FLNA	33	0.004649	1087030	0.310146
Down	COL1A1	32	0.008312	1395294	0.32942
Down	DLL1	31	0.006383	1006300	0.324583
Down	JAG1	29	0.005281	874336	0.325033
Down	PDE9A	29	0.003164	644058	0.281577
Down	AGTR1	28	0.004101	926250	0.304088
Down	TNNT3	27	1.64E-04	89708	0.268585
Down	MYO10	27	0.002183	551478	0.325892
Down	GPC4	26	0.001618	1207760	0.258652
Down	IGFBP3	26	0.004163	894182	0.300288
Down	ABCE1	25	0.007191	831802	0.321973
Down	TIMP1	23	0.006574	950444	0.322905
Down	VTN	23	0.005502	970948	0.284138
Down	ARAP3	23	8.48E-04	298776	0.326642
Down	COL1A2	23	0.001462	373484	0.28554
Down	B2M	23	0.00758	619198	0.322505
Down	TBCB	22	0.002726	428028	0.322705
Down	VASN	22	0.003962	582444	0.343574
Down	LGALS1	21	0.004371	578082	0.333903
Down	CD81	21	0.005039	710796	0.323708
Down	VCAM1	21	0.003333	2717522	0.2699
Down	THY1	21	0.003795	675432	0.288956
Down	PHGDH	21	0.004117	689964	0.323999
Down	ITPR3	21	0.003472	727920	0.327326
Down	TGFB3	20	0.002631	725004	0.278316
Down	BIN1	20	0.002083	351704	0.291835
Down	LPAR1	20	0.001469	1296676	0.242258
Down	MSX1	20	0.003633	648486	0.289134
Down	SLIT2	20	0.001084	281232	0.291273
Down	SHMT2	19	0.005637	547666	0.32215
Down	COL4A1	19	0.001742	983934	0.257813
Down	RAB3IL1	19	0.002314	1857444	0.231054
Down	SPARC	17	0.002023	197820	0.275923
Down	VCAN	17	0.003487	561304	0.267405
Down	LDB2	17	0.003396	1291388	0.254812
Down	DPYSL2	17	0.003321	506826	0.325869
Down	MAF	17	0.001088	288082	0.289456
Down	PARVA	16	0.003041	421786	0.323731
Down	TNFRSF1B	16	0.001419	325188	0.32382
Down	FBLN2	16	0.001835	589690	0.249987
Down	EEF2K	15	0.001411	364288	0.323083
Down	TEAD2	15	7.99E-04	352390	0.324066
Down	TAGLN	15	0.001241	205764	0.280381
Down	FASN	15	0.001757	367956	0.322084
Down	CD36	15	0.002116	386412	0.294661
Down	NDN	15	0.003831	473694	0.322239
Down	ADAM15	15	0.001982	294010	0.331283
Down	ARHGEF2	15	9.41E-04	262426	0.330396
Down	PEMT	14	0.005116	629532	0.293664
Down	VWF	14	0.001828	345586	0.275097
Down	OXTR	14	0.001359	1221820	0.23325
Down	FRYL	14	0.001994	332012	0.321598
Down	AGRN	14	0.001733	263834	0.326482
Down	LFNG	13	0.001654	331212	0.264357
Down	ARHGEF6	13	0.001032	179796	0.326573
Down	TSC22D3	13	1.34E-04	119696	0.32391
Down	IMPDH1	13	0.002712	390200	0.321554
Down	NME4	12	0.003215	901430	0.228485
Down	EHD2	12	0.003128	309602	0.320717
Down	RGL1	12	5.53E-04	670384	0.247308
Down	COL18A1	12	0.001098	309928	0.266008
Down	ADGRA2	12	8.13E-04	196338	0.301583
Down	FMOD	11	2.68E-04	98450	0.300385
Down	SLIT3	10	6.95E-05	22762	0.24207
Down	COL5A1	3	4.31E-05	14682	0.244636
Down	TGFBI	3	8.62E-06	14986	0.248607
Down	RASIP1	2	1.64E-06	1660	0.251732
Down	CAV2	2	0	0	0.285836
Down	PCOLCE	2	3.25E-05	6584	0.246761
Down	COL4A2	2	0	0	0.208517
Down	SVIL	2	0	0	0.262801
Down	SMTN	2	7.00E-06	2536	0.261073
Down	COL4A5	2	7.45E-06	6672	0.244776
Down	FSCN1	2	2.41E-06	2090	0.268585
Down	ADAMTS1	2	5.19E-05	3268	0.250857
Down	CTSC	1	0	0	0.244559
Down	FEZ1	1	0	0	0.21526
Down	MALL	1	0	0	0.269357
Down	LYL1	1	0	0	0.248489
Down	SEMA3A	1	0	0	0.27858
Down	ENPP2	1	0	0	0.195022
Down	BST2	1	0	0	0.24757
Down	F3	1	0	0	0.236738
Down	COL16A1	1	0	0	0.204978
Down	ANGPTL2	1	0	0	0.252724
Down	NCALD	1	0	0	0.250508
Down	RASL12	1	0	0	0.228262
Down	PPP1R14A	1	0	0	0.273923
Down	FCGRT	1	0	0	0.243872
Down	CNN2	1	0	0	0.268139
Down	EHBP1	1	0	0	0.242848
Down	COL3A1	1	0	0	0.216264
Down	DDIT4	1	0	0	0.25408
Down	ITM2C	1	0	0	0.249441
Down	GAS6	1	0	0	0.257007
Down	FERMT2	1	0	0	0.252751
Down	RAPGEF5	1	0	0	0.246424
Down	APCDD1	1	0	0	0.230588
Down	MMP23B	1	0	0	0.200599
Down	PTPRD	1	0	0	0.274549
Down	RSPO3	1	0	0	0.249441
Down	COL6A1	1	0	0	0.243745
Down	DDR2	1	0	0	0.247805
Down	NEK6	1	0	0	0.244776
Down	COL5A2	1	0	0	0.205788
Down	TSPAN4	1	0	0	0.244559
Down	IFITM3	1	0	0	0.27858
Down	HES4	1	0	0	0.261875
Down	FAT1	1	0	0	0.242521