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. 2021 Apr 27;10(5):1027. doi: 10.3390/cells10051027

Figure 5.

Figure 5

Histoarchitectonics and immunophenotype of CTLA-4(+) tonsillar cells stained with antibodies of the clone CAL49. (a) Histotopography of CTLA-4(+) cells in the lymphatic follicle and in the extrafollicular lymphoid tissue of the tonsil. In the lymphatic follicles, CTLA-4(+) cells are localized mainly within the germination center. (b) Fragment of the light zone of the germination center; the intracellular co-expression of CTLA-4 and CD3 is clearly visible. (c–c″) Cytological features of the intracellular co-localization of CTLA-4 immunopositive material and CD3 in lymphocytes. (d–d″) There was a lack of expression of CD3 in CTLA-4(+) cell. (e,f,g–g″) Co-expression variants of CTLA-4 + and CD4. The predominant location of CD4+ lymphocytes and CTLA-4(+) cells was in the germinal center of the lymphatic follicle, with most CTLA-4(+) cells expressing CD4. The presence of CD4-negative CTLA-4(+) cells (g) is noteworthy. Scale bar: 125 μm (a), 50 μm (b,e,f), 10 μm (the rest).